Summary
Summary Pharmaceutical thermal processing
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Industrial pharmacy - 1st semester Includes bullet points, key diagrams and images
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Pharmaceutical Thermal Processing Thermal processing also known as fusion
Used when attempting to control the release or solubility of the API
2 aspects controlling bioavailability are intestinal permeability and solubility of the
drug
Processing technique chosen by drugs physical and chemical properties
Prepare drugs in a matrix without a solvent- Solid dispersion
Solid Dispersion
One or more active ingredients in an inert carrier or matrix at a solid state prepared
by melting, solvent or melting solvent method
Melt Mixing
Liquefy an excipient (lipid or low MW polymer) then mix and heat using a stir bar or
impeller to combine with the drug
Liquefied excipient acts as a solvent therefore improving dissolution meaning better
bioavailability
Spray Congealing
Downstream of melt mixing, rapid solidification of discrete droplets of the melt
(atomised)
Microspheres have improved dissolution compared to crystals
Can reduced GI irritation and improve bioavailability
Sintering/Curing
Thermal process that fuses powder particles
Used for m/r formulations
Fuses powder particles together forming a
layer
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