Summary
Summary Pharmaceutical materials
- Course
- Institution
Industrial pharmacy - 1st semester Includes bullet points, key diagrams and images
[Show more]
Seller
Follow
alexd1
Content preview
Materials Altering solid form alters- bioavailability, stability, manufacturing and
regulatory processes
Bioavailability- drug must be in solution to cross GI tract and rate limiting
step is usually rate of dissolution
Stability- chemical reactivity, conversion to other compounds and forms
may have different flow, compression and water sorption properties
Regulation- can patent different forms of drug and first steps of drug is to
characterise its form
Arrangement of molecules:
Crystalline materials-ordered and periodic arrangement, unit cell
repeated in all directions and have a melting point
Amorphous materials- no long range order, non-
random local structure and have a glass transition
temperature (Tg)
Crystal systems- symmetrical arrangement
System Axes Angles
Cubic a=b=c α=β=γ=90o
Tetragonal a=b≠c α=β=γ=90o
Orthorhombic a≠b≠c α=β=γ=90o
Monoclinic a≠b≠c α= γ=90o≠β
Triclinic a≠b≠c α≠β≠γ
Trigonal a=b=c α≠β≠γ≠90o
Hexagonal a=b≠c α=β=90o, γ=120o
Polymorphism- can have different crystal structures of
the same compound
Have different melting points and solubilities
Same solution/melt
Polymorphic stability- at a given temperature and pressure only 1 form is
stable (with lowest free energy) but others can be meta stable (kinetically
stable)
Monotropic- same form is stable irrespective of temperature
Enantiotropic- either of 2 forms can be stable depending on temperature
(critical temperature +n=form 1 or –n=form 2
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller alexd1. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $3.97. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
84146 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now