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Samenvatting - galenica oplossingen
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Samenvatting - galenica: oplossingen
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OPLOSSINGEN/SIROPEN –OOGDRUPPELS
SIROPEN
DEFINITIE
SIROPEN: = Vloeibare, visceuze, zoete bereiding door hoog gehalte aan:
1) suiker (saccharose, glucose, …)
2) zoetsmakende meerwaardige alcoholen (sorbitol, glycerol)
• Uitwendige fase: Sirupus Simplex BFV
(saccharose 65% g/g)
Sorbitol 70% (diabetici)
• Orale toediening
EIGENSCHAPPEN
Voordelen:
• kinderen, ouderen
• slecht smakende geneesmiddelen maskeren
• slecht oplosbare geneesmiddelen
• (hydrotrope eigenschappen van siroop)
• Dichtheid van stroop: 1.3 g/ml
100 ml stroop ≈ 130 g of 100 g stroop ≈ 77 ml
SAMENSTELLING
R/ Geneesmiddel
Hulpstoffen
Oplosmiddel (en) enkel oplosmiddelen geschikt voor IG = inwendig gebruik
- water (aqua purificata)
- glycerine
- ethanol ‘goede smaak’
Suiker- of sorbitolstroop
, SAMENSTELLING: STROOP
• Suikerstroop = sirupus simplex BFV = enkelvoudige stroop BFV
• Oplossing van 65g saccharose in 35 g gezuiverd water ;Bereiding : warm/koud(percolatie)
• Sorbitolstroop = solutio edulcorans sine saccharo
NFV = zoete oplossing zonder suiker
• Oplossing van 70g sorbitol in 30 g gedestilleerd water
Aangewend bij diabetici
BEREIDING
VOORBEREIDING
• Geneesmiddel:
o maximale dosis
o oplosbaarheid
o stabiliteit
o fijnheidsgraad
• Onverenigbaarheden in het recept
• Keuze geschikte oplosmiddelen
• Uitdrukking concentraties in recept
o eindvolume: in maatglas
o eindgewicht: in getarreerd recipiënt (balans)
(hou rekening met dichtheid van siroop, alcohol, extracten, …)
BEREIDING SIROOP
Geneesmiddel afwegen of afmeten
• Volgorde van mengen:
1. Waterige geneesmiddeloplossingen
2. Stroop, glycerine (tussenstof)
3. Tincturen / Alcoholische oplossingen
4. Vloeibare extracten
5. Stroop en/of water
• Telkens grondig mengen
• Verder: cfr. oplossinge
CONTROLES
Helderheid, Neerslag en pH
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