Summary
Samenvatting - galenica zalven
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dit deel bevat alles over zalven
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maarendehouwer
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CRÉMES EN EMULSIES• ZALF (1 fase)
- Hydrofobe, waterabsorberende, hydrofiele
- GM opgelost of gesuspendeerd in zalfbasis
• CREME (2 fasen: lipofiele fase + waterfase)
- O/W of W/O, (emulgatoren)
- GM opgelost of gesuspendeerd in crèmebasis
WERKING
• Lokaal
• Systemisch
• Opname farmacon in huid afhankelijk van :
Fysicochemische eigenschappen farmacon
Samenstelling vehiculum
Toestand van huid, plaats op lichaam, leeftijd,..
• Farmaceutische versus biologische beschikbaarheid.
Grootste barriëre: stratum corneum – watergehalte slechts 20%
• Beste permeatie: lipofiel/hydrofiel (inter is tussen) (trans is door)
Als je een plakker plakt (hydratatie) gaat intracellulair gemakkelijker doordat (gaten) groter worden
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