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Summary OCR A-Level Biology 6.2.8 Epistasis
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EpistasisDominant Epistasis
Presence of a dominant epistatic gene prevents the expression of a hypostatic gene,
regardless of its dominance
Dominant epistatic gene in Labradors means that black pigment is produced which
overrides the pigment produced by the hypostatic gene, leading to black fur
12:3:1 Example:
o A is a dominant epistatic gene coding for no pigment
o B is a hypostatic gene coding for yellow pigment
o b is a hypostatic gene coding for green pigment
Parent Phenotype Double Heterozygous x Double Heterozygous
Parent Genotype AaBb x AaBb
Parent Gametes AB Ab aB ab AB Ab aB ab
Dihybrid Cross AB Ab aB ab
A AAB AAB
AABB AaBb
B b b
A AAb
AABb AaBb Aabb
b b
AAB
aB AaBb aaBB aaBb
b
ab AaBb Aabb aaBb aabb
Ratio White = 12
Yellow = 3
Green = 1
13:3 Example:
o A is a dominant recessive gene coding for no pigment
o B is a hypostatic gene coding for brown pigment
Parent Phenotype Double Heterozygous x Double Heterozygous
Parent Genotype AaBb x AaBb
Parent Gametes AB Ab aB ab AB Ab aB ab
Dihybrid Cross AB Ab aB ab
A AAB
AABB AaBb AABb
B b
Ab AABb AAbb AaBb Aabb
AAB
aB AaBb aaBB aaBb
b
ab AaBb Aabb aaBb aabb
Ratio White = 13
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