Brad and Rocky drink equivalent amounts of alcohol (and have the same
3 views 0 purchase
Course
HBO Small Business en Ondernemerschap
Institution
HBO Small Business En Ondernemerschap
Brad and Rocky drink equivalent amounts of alcohol (and have the same body mass) would you
predict that Brad's levels of acetaldehyde are higher or lower when compared to Rocky? Explain
your answer. Brad: Fast ADH; Slow ALDH Rocky: Fast ADH; Fast ALDH High levels of
acetaldehyde make drinking un...
Brad and Rocky drink equivalent amounts of alcohol (and have the same body mass) would you
predict that Brad\'s levels of acetaldehyde are higher or lower when compared to Rocky? Explain
your answer. Brad: Fast ADH; Slow ALDH Rocky: Fast ADH; Fast ALDH High levels of
acetaldehyde make drinking unpleasant, resulting in facial flushing, nausea, and a rapid
heartbeat. With all other environmental and genetic factors being equal, Rocky is at higher risk
for alcoholism than Brad. Explain this statement.
Solution
Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are enzymes involved in
the metabolism of alcohol. ADH catalyses the conversion of ethanol to acetaldehyde. ALDH
converts acetaldehyde to acetate.
Brad has Fast ADH, so he would have rapid production of acetaledehyde from the consumed
ethanol. Because he also has slow ALDH, the produced acetaldehyde would not be properly
converted into acetate. This could lead to accumulation of acetaldehyde. As levels of
acetaldehyde increases, there are various unpleasant consequences, and this should discourage
Brad from drinking further.
Rocky, on the other hand, has fast ADH and fast ALDH. In his body, ethanol is metabolized
more quickly. As acetaldehyde is produced by ADH, it is rapidly converted into acetate by fast
ALDH. Since there is no accumulation of acetaldehyde, we can expect Rocky to drink more.
Therefore, Rocky is at higher risk for alcoholism than Brad.
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller meejuhaszjasmynspe52866. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $7.27. You're not tied to anything after your purchase.