100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Samenvatting farmaco 1E ZIT GEHAALD $9.17   Add to cart

Summary

Samenvatting farmaco 1E ZIT GEHAALD

 22 views  0 purchase
  • Course
  • Institution

Volledige samenvatting van farmacokinetiek en dynamiek

Preview 4 out of 54  pages

  • June 27, 2023
  • 54
  • 2022/2023
  • Summary
avatar-seller
2023




ALGEMENE
FARMACOLOGI
E
FARMACOKINETIEK EN FARMACODYNAMIEK

,Inhoudsopgave
Introductie..............................................................................................................................................5
Voorstelling van PK Parameters..........................................................................................................5
Fysicochemische eigenschappen en permeabiliteit...............................................................................6
Dissolutie............................................................................................................................................6
Absorptie van geneesmiddelen in de pens.....................................................................................6
Fysicochemische eigenschappen........................................................................................................7
Ionisatiegraad en pH.......................................................................................................................7
Polariteit.........................................................................................................................................7
Permeabiliteit.....................................................................................................................................8
Passief transport.............................................................................................................................8
Carrier-gemedieerd transport........................................................................................................9
Pinocytose/endocytose..................................................................................................................9
BCS classificatie................................................................................................................................10
ADME....................................................................................................................................................11
Absorptie of resorptie.......................................................................................................................11
Parenterale toedieningsroute.......................................................................................................11
Enterale toedieningsroute............................................................................................................11
Fysiologie van GI en belang bij absorptie......................................................................................12
Beïnvloeding maaglediging...........................................................................................................12
Distributie.........................................................................................................................................13
Permeabiliteit en perfusie............................................................................................................13
Schijnbaar verdelingsvolume V.....................................................................................................14
Eiwit/weefselbinding....................................................................................................................15
Metabolisme.....................................................................................................................................16
First pass effect.............................................................................................................................17
Niet-lineaire kinetiek....................................................................................................................17
Klaring...........................................................................................................................................17
Geneesmiddelinteracties..............................................................................................................18
Excretie.............................................................................................................................................19
Renaal...........................................................................................................................................19
Gal................................................................................................................................................20
Farmacokinetische modellen................................................................................................................21
PK parameters..................................................................................................................................21
Niet-compartimentele analyse.........................................................................................................22

, PK modellen......................................................................................................................................22
Empirisch......................................................................................................................................22
Compartimenteel..........................................................................................................................22
Fysiologisch...................................................................................................................................22
Verschil 0e en 1e orde kinetiek..........................................................................................................22
1e orde kinetiek.................................................................................................................................22
1-compartiment model.................................................................................................................23
2-compartiment model.................................................................................................................24
Orale dosering = absorptiemodel.....................................................................................................25
0e orde kinetiek.................................................................................................................................26
Oorzaken van niet-lineaire kinetiek..............................................................................................27
Interspecies schaling.........................................................................................................................27
Allometrie.....................................................................................................................................27
Meervoudige toediening en infuus...................................................................................................27
PK/PD evaluatie....................................................................................................................................28
Indeling concentratie-effect relaties.................................................................................................28
Direct............................................................................................................................................29
Indirect.........................................................................................................................................29
Modellen concentratie-effect relaties..............................................................................................29
Direct link model..........................................................................................................................30
Indirect Link model (= Effect compartiment model).....................................................................31
indirect reversibel effect (turnover model)..................................................................................32
Indirect respons model.................................................................................................................32
Optreden van tolerantie...................................................................................................................34
Counter regulatoir effect: Nifedipine............................................................................................34
Receptor down- of upregulatie: Tolerantie..................................................................................35
Depletie precursoren: tolerantie nitraten....................................................................................35
Waarde van PK/PD...........................................................................................................................35
Voorbeeld van 2 NSAIDs: COX1 en COX2......................................................................................36
Vergelijking PD verschillende GM.................................................................................................36
Inleiding................................................................................................................................................38
Weinig specifiek................................................................................................................................38
Specifiek...........................................................................................................................................39
Biologische specificiteit................................................................................................................39
Chemische specificiteit.................................................................................................................39
Aangrijpingspunten geneesmiddelen – voorbeelden...........................................................................39

, Maagzuurklachten............................................................................................................................39
H2 antagonisten...........................................................................................................................40
Protonpomp inhibitor (PPI)...........................................................................................................40
Ischemisch herseninfarct..................................................................................................................41
Virchow’s triad..............................................................................................................................42
Stollingscascaderemmers.............................................................................................................42
Plaatjesremmers...........................................................................................................................42
Adrenerg system...............................................................................................................................43
Gladde spiercel.............................................................................................................................44
Hartspiercel..................................................................................................................................44
Biologische selectiviteit................................................................................................................45
Cardiovasculaire geneesmiddelen................................................................................................45
Adrenerge effecten.......................................................................................................................46
Reuma/Reumatoïde arthritis (RA)....................................................................................................47
Geneesmiddelen bij reumatoïde arthritis.....................................................................................47
Receptoren...........................................................................................................................................48
Geneesmiddel-receptor interacties..................................................................................................49
Agonist..........................................................................................................................................49
Two-state receptor model............................................................................................................49
Allosterische modulatie................................................................................................................50
Antagonist....................................................................................................................................50
Adaptatie en therapeutische index...............................................................................................52

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller dgkstudentantwerpen. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for $9.17. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

67474 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy study notes for 14 years now

Start selling
$9.17
  • (0)
  Add to cart