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HR (Human Reproduction) Lactation and Neonatal Physiology
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  • Course
  • Medicine (A100)
  • Institution
  • Cambridge University (CAM)

University of Cambridge (Medicine 1st class): Summary of key points of HR (Human Reproduction) Lactation and Neonatal Physiology lectures for 2nd year.

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Document information

  • June 29, 2023
  • 4
  • 2022/2023
  • Class notes
  • Dino giussani
  • All classes

Subjects

  • human reproduction
  • lactation
  • neonatal physiology
  • cambridge
  • 2023
  • medicine
  • hr
  • lactation and neonatal physiology
  • lecture notes

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  • Cambridge University (CAM)
  • Unknown
  • Medicine (A100)
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HR (Human Reproduction) Lecture Notes: Lactation
and Neonatal Physiology
Preterm birth is 10% pregnancies developed countries, 25% in undeveloped -
half end in death

Fetal ventilation
● Lung fluid creates pressure, tissues respond to pressure to grow
○ Secretion: Cl- channels, water follows
○ Before birth: adrenaline increases -> cAMP -> inhibited Cl-, more

ENaCs -> reabsorption
◆ Amiloride, triamterene can block these ENaCs
● Bounds of lung exercise of ventilating fluid (diaphragm EMG) when
awake (asynchronous EEG)
○ -> thinner septae, more dilated bronchioles
○ By birth not ventilating (finished exercise)
● At birth stimuli to first breath
○ Grunts against closed glottis
○ Generalised arousal
○ Hypoxia and hypercapnia from tying umbilical cord


Surfactant (differing surface tension at different radii to counteract La place (P
= 2T/r)
● Turnover
○ Type II (glandular epithelium) secrete surfactant into osmiophillic

lamellar bodies
○ Bodies unravel into lattice (tubular myelin) with phospholipids in

the gaps
○ Phospholipids are absorbed
○ Remaining phospholipids (90%) are collected into multi-vesicular

structures then reuptake or macrophage degradation
● Dipalmitoyl-phosphatidyl-choline
○ SP-A-D
○ B,C,D involved in lung ventilation function
○ A,D (aka collectins) involved in lung immune function


Cortisol matures lung (use glucocorticoids in mothers threatened with preterm
delivery)
● Upregulates beta receptors in lung
● Increases PNMT in adrenal gland
● Increases activity of deiodinase and hence T3 production (also helps
mature lung)
● Increases surfactant production

Thermoregulation
● Losing heat

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