Genetics - ANSWER - The study of genes and their role in inheritance
Genomics - ANSWER - The study of all a person's genes
Epigenetics - ANSWER - The study of chemical modification of specific genes
Germline - ANSWER - Inherited from parent
Somatic - ANSWER - Acquired
Anemia - ANSWER...
Genetics - ANSWER - The study of genes and their role in inheritance
Genomics - ANSWER - The study of all a person's genes
Epigenetics - ANSWER - The study of chemical modification of specific genes
Germline - ANSWER - Inherited from parent
Somatic - ANSWER - Acquired
Anemia - ANSWER - Deficiency in erythrocytes (RBCs)
Anemia is diagnosed by - ANSWER - CBC
Blood smear
Anemia clinical manifestations based on severity - ANSWER - Mild (Hgb 10-12) - no symptoms at rest,
mild fatigue with exertion
Moderate (Hgb 6-10) - cardiopulmonary symptoms that occur at rest
Severe (Hgb <6) - Multiple systems involved
Tx by supportive care, HSCT, and immunosuppressive therapy in those >55
Anemia caused by acute blood loss - ANSWER - Occurs from hemorrhage
10% 500ml loss - no symptoms
20% 1000ml loss - no symptoms at rest, tachycardia with exercise, mild postural hypotension
30% 1500 ml loss - normal BP and pulse at rest, tachycardia and postural hypotension with exercise
40% 2000 ml loss - BP, CVP, and CO below normal, air hunger, rapid, thready pulse, cool, clammy skin
50% 2500ml loss - shock, lactic acidosis, possible death
, Tx by replacing fluid volume (lactated ringers, albumin), identify and correct source of blood loss, blood
transfusion, replace platelets, and supplement iron if needed
Thrombocytopenia - ANSWER - Low platelet count
Platelet count below 150,000
Results in abnormal hemostasis (prolonged bleeding from injury or spontaneous bleeding)
3 types: ITP, TTP, and HIT
S/S include mucosal/cutaneous bleeding (epistaxis, petechiae, purpura, abnormal bleeding, after
venipuncture/IM injections, internal bleeding
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