Hand-made digital notes and diagrams on the entirety of Immunity
Topic written spec-by-spec point to ensure all content is covered
Compatible with all exam boards but predominantly CIE
Describe the action of phagocytes (macrophages and neutrophils)
to
response
/ broad Muff of
s
✗ non-specific
pathogen↳ sinan ser of
@✗ ten of receptors
spent'
many types of receptors
✗ ↳
respond
to
Phagocytes are white blood cells that are
produced continuously in the bone marrow
stored in bone marrow , then distributed to the rest
of
the
body
J T
neutrophil
y
remove dead cells and invasive
muiooryaninus
macrophage
lymphocyte
carry
out non
specific immune response
-
ao un]
-
types of phagocyte macrophages
there two main and
are
neutrophils
:
[60-652]
Neutrophils
large numbers from
→ released in their stoves
→ short-lived cells
→ lobed nucleus
-
, ⑧
% Pathogen
Neutrophil mode
of action :
Chemotaxis
Be
Neutrophil
-
1 .
Pathogen secretes chemicals to stimulate
receptors
2 .
Phagocyte moves towards chemical snniulus
)%
: chemotaxis
Receptor for annisocy Recognition
& Attainment
3 .
Phagocyte engulfs pathogen by endocytosis of pathogen
mama
by antibody
by extending a
pseudopod
together by
this is made easier when
antibodies in a
pathogens
process
caved
are stuck
agglutination
]§ Endocytosis
]
4 .
Pathogen stoned in a vesicle Lysosomes
digestive
with
engines
S Venite
fuses lysosome
. with a which
contains
digestive enzymes that help break down the
putting
lysosome
with
fuses
venire
6.
via
Pathogen destroyed by engines and
exits an
exocytosis
Macrophages ÷÷÷) Bacteria
digested
→
layer than neutrophils
Ivied
long
→ -
cells
&
→ don't remain in the blood , move into
organs lymph nodes
travel in blood
→ as
monocytes
Mauophuge mode
of action
destroy pathogens completely
→ donor
-1 cut
pathogens up
to
display antigens of pathogen on their surface
the
→
antigen-presenting an can now be
recognised by lymphocytes
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