Case
BMW3010 - Multimorbiditeit in Obesitas - Case 5
- Course
- Institution
BMW3010 - Multimorbiditeit in Obesitas - Case 5 Other cases are following soon!
[Show more]
Seller
Follow
Truus93
Content preview
BMW3010 – Multimorbiditeit in Obesitas – Case 5HOW DOES NORMAL FAT /HORMONAL -METABOLISM IN THE LIVER FUNCTION ?
Exogenous pathway
Dietary lipids are emulsified by bile acids, then hydrolyzed, absorbed and packaged into
chylomicrons, which are released into lymphatic vessels. At this moment, the
chylomicrons contain:
Cholesteryl esters
Phospholipids
Triglycerides
ApoB48
In the blood stream, the chylomicrons acquire ApoC2 and ApoE from HDLs, resulting in
formation of their mature shape. After LPL-mediated hydrolysis in the capillaries of adipose
and muscle tissue, CRs residuals re-enter into the bloodstream to be taken up by the
liver (receptor mediated, LDLR), where the lipid content is further hydrolyzed and used for
the synthesis of VLDLs, or otherwise used in the beta-oxidation.
Endogenous pathway
VLDLs contain ApoB100 with a small amount of triglycerides, phospholipids and cholesteryl
esters. In the bloodstream, they acquire ApoC2 and ApoE from HDLs, and release free
FAs to muscle and adipose tissue after LPL activation. VLDLs now transform into
intermediate density lipoproteins, which are removed by the liver (1) or, after further
lipase activity, become low-density lipoproteins (LDL) (2). The uptake of all
lipoproteins is mediated by the LDL Receptor (LDLR).
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Truus93. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $3.24. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
67866 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now