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Test bank for Modern Blood Banking and Transfusion Practices 7th Edition by Denise M. Harmening
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Test bank for Modern Blood Banking and Transfusion Practices 7th Edition by Denise M. Harmening Table of Contents Chapter 1. Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends ............................................. 3 Answer Section ...........................

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Test bank for Modern Blood Banking and Transfusion Practices 7th Edition by Denise M.
Harmening

Table of Contents
Chapter 1. Red Blood Cells and Platelet Preservation: Historical Perspectives and CurrentTrends ............................................. 3
Answer Section .......................................................................................................................................................................... 8
Chapter 2. Basic Genetics ............................................................................................................................................................ 11
Answer Section ........................................................................................................................................................................ 15
Chapter 3. Fundamentals of Immunology.................................................................................................................................... 18
Answer Section ........................................................................................................................................................................ 26
Chapter 4. Concepts in Molecular Biology .................................................................................................................................. 30
Answer Section ........................................................................................................................................................................ 35
Chapter 5. The Antiglobulin Test ................................................................................................................................................ 38
Answer Section ........................................................................................................................................................................ 44
Chapter 6. The ABO Blood Group System ................................................................................................................................. 47
Answer Section ........................................................................................................................................................................ 55
Chapter 7. The Rh Blood Group System ..................................................................................................................................... 59
Answer Section ........................................................................................................................................................................ 64
Chapter 8. Blood Group Terminology and the Other Blood Groups ........................................................................................... 68
Answer Section ........................................................................................................................................................................ 92
Chapter 9. Detection and Identification of Antibodies .............................................................................................................. 102
Answer Section ...................................................................................................................................................................... 112
Chapter 10. Pre-Transfusion Testing ......................................................................................................................................... 116
Answer Section ...................................................................................................................................................................... 124
Chapter 11. Overview of the Routine Blood Bank Laboratory.................................................................................................. 127
Answer Section ...................................................................................................................................................................... 131
Chapter 12. Other Technologies and Automation ..................................................................................................................... 133
Answer Section ...................................................................................................................................................................... 136
Chapter 13. Donor Screening and Component Preparation ....................................................................................................... 138
Answer Section ...................................................................................................................................................................... 142
Chapter 14. Apheresis ................................................................................................................................................................ 144
Answer Section ...................................................................................................................................................................... 150
Chapter 15. Transfusion Therapy .............................................................................................................................................. 156
Answer Section ...................................................................................................................................................................... 169
Chapter 16. Adverse Effects of Blood Transfusion ................................................................................................................... 174
Answer Section ...................................................................................................................................................................... 185
Chapter 17. Cellular Therapy..................................................................................................................................................... 189
Answer Section ...................................................................................................................................................................... 191
Chapter 18 .................................................................................................................................................................................. 192
Answer Section ...................................................................................................................................................................... 200
Chapter 19. Hemolytic Disease of the Fetus and Newborn ....................................................................................................... 202
Answer Section ...................................................................................................................................................................... 209
Chapter 20. Autoimmune Hemolytic Anemias .......................................................................................................................... 212 1

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Answer Section ...................................................................................................................................................................... 219
Chapter 21. The HLA System .................................................................................................................................................... 223
Answer Section ...................................................................................................................................................................... 228
Chapter 22. Relationship Testing............................................................................................................................................... 231
Answer Section ...................................................................................................................................................................... 234
Chapter 23. Quality Management .............................................................................................................................................. 236
Answer Section ...................................................................................................................................................................... 239
Chapter 24 .................................................................................................................................................................................. 241
Answer Section ...................................................................................................................................................................... 250
Chapter 25. Transfusion Safety and Federal Regulatory Requirements .................................................................................... 252
Answer Section ...................................................................................................................................................................... 255
Chapter 26. Laboratory Information Systems ............................................................................................................................ 257
Answer Section ...................................................................................................................................................................... 261
Chapter 27. Medicolegal and Ethical Aspects of Providing Blood Collection and TransfusionServices .................................. 263
Answer Section ...................................................................................................................................................................... 267
Chapter 28. Tissue Banking: A New Role for the Transfusion Service ...................................................................................... 269
Answer Section ...................................................................................................................................................................... 271




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Chapter 1. Red Blood Cells and Platelet Preservation: Historical Perspectives and Current
Trends

Multiple Choice
Identify the choice that best completes the statement or answers the question.

1. Which metabolic pathway is responsible for generating 90% of the ATP for the RBC?
a. Pentose phosphate shunt c. Glycolysis
b. Luebering-Rapoport shunt d. Methemoglobin reductase

2. A unit of blood was returned to the blood bank before it was spiked. Apparently the patient’s IV
failed.
The unit of blood was outside the blood bank for 35 minutes. Which of the statements below
is most accurate? a. The unit of blood should be discarded immediately.
b. The unit of blood can be returned to inventory.
c. The unit of blood must be transfused within 4 hours or be discarded at the end of that time.
d. The unit of blood must be transfused with 24 hours.

3. What is the average diameter of a platelet?
a. 5 to 10 µm c. 1 to 2 µm
b. 2 to 4 µm d. 4 to 6 µm

4. In the normal hemoglobin-oxygen dissociation curve, what percentage of oxygen is released to
the tissues when PO2 averages 40 mm Hg?
a. 75% c. 100%
b. 25% d. 50%

5. What factors are known to influence platelet metabolism and function?
a. Storage temperature c. Platelet count
b. Initial pH d. All of the above

6. Which of the following red blood cell morphologies may be present on the peripheral blood
smear as a result of loss of RBC membrane?
a. Spherocytes c. Burr cells
b. Target cells d. Schistocytes

7. What does the term autologous transfusion refer to?
a. A parent donating blood for his or her child
b. An individual donating blood for a friend
c. An individual donating blood for a relative
d. An individual donating blood for his or her own transfusion

8. What is the primary function of hemoglobin?
a. Iron metabolism c. Oxygen transport
b. Porphyrin synthesis d. Signal transduction




3

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9. All of the following areas of red blood cell biology are crucial for normal erythrocyte survival except:
a. cellular metabolism. c. site of the ABO antigen attachment.
b. RBC membrane. d. hemoglobin structure.

10. What is the correct biochemical composition of the RBC membrane?
a. 52% protein, 40% lipid, 8% carbohydrate
b. 40% protein, 8% lipid, 52% carbohydrate
c. 8% protein, 52% lipid, 40% carbohydrate
d. 8% lipid, 40% carbohydrate, 52% protein

11. All of the following biochemical changes are associated with loss of red blood cell viability upon storage
except:
a. decreased pH. c. increased ATP level.
b. loss of red blood cell function.d. decreased glucose consumption.

12. Which red blood cell preservative has a storage time of 35 days?
a. ACD c. AS-1
b. CPDA-1 d. CPD

13. The RBC membrane is relatively permeable to all of the following except:
a. chloride. c. bicarbonate.
b. sodium. d. water.

14. What percentage of platelets is sequestered in the spleen as functional reserve after being released
from the bone marrow?
a. 30% c. 10%
b. 50% d. 25%

15. What is the major biochemical consideration in platelet storage?
a. Glucose metabolism c. Production of carbon dioxide
b. Oxygen supply d. Regulation of pH

16. What would the hemoglobin-oxygen dissociation curve depict in a patient exhibiting clinical signs of
alkalosis?
a. Normal c. Shift to the right
b. Shift to the left d. None of the above

17. Name the main lipid components of a red blood cell membrane.
a. Phospholipid c. Glycolipid
b. Sphingomyelin d. Glycophorin A

18. The ABO blood groups were discovered in 1901 by whom?
a. Charles Drew c. Loutit and Mollison
b. Karl Landsteiner d. Edward Lindeman




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