NR 546 Advanced Pharmacology MIDTERM STUDYGUIDE WEEK 1-4 Revised Latest.

NR 546 Advanced Pharmacology MIDTERM STUDYGUIDE WEEK 1-4 Revised Latest. Typical antipsychotics (conventional) (FGA)  Treats positive (+) symptoms only appropriate for the acute and chronic management of schizophrenia and psychosis.  Non-selectively blocks dopamine D2 receptors, specifically in mesolimbic pathway; also blocks Ach (Muscarinic), histamine, NE Five main SE of FGAs  Sedation  Postural Hypotension  Lower seizure threshold  Anticholinergic side effects  Photosensitive Haloperidol-High-Appropriate for acute, severe agitation and aggression-Butyrophenones  Initial oral dose 1-15mg/day (can give once daily or divide;  Usual dose 1-40mg/day (orally);  Max dose 100mg/day  Tablets 0.5, 1, 2, 5, 10, 20mg; Concentrate 2mg/ml; Injection 5mg/ml  Half-life 13-38  Higher risk for EPS and TD  Avoid in older adults due to increased risk of cerebrovascular accident (CVA), cognitive decline, and death in persons with dementia and with dementia-related psychosis. Fluphenazine-Medium-Psychotic D/Os  Initial oral dose 0.5-10mg/day divided doses;  Usual dose 1-20mg day;  Max dose40mg/day  Tablet 1, 2.5, 5, 10mg; Elixer 2.5mg/ml; Concentrate 5mg/ml  Half-life 15 hours Thiothixene-Medium  Initial dose 5-10mg/day;  Usual dose 15-30mg/day;  Max dose 60mg/day divided  Capsules 2, 5, 10mg  Half-life 3.4-34 hours Thioridazine-Low-2nd line due to QTc issues  Initial dose 50-100mg/3xday/increase gradually;  Usual dose 200-800mg divided;  Max dose 800mg/day  Tablets 10, 15, 25, 50, 100mg  Metabolized by CYP450 2D6 Chlorpromazine-Low-2nd line due to QTc issues -schizophrenia-DA 2 antagonist  Usual dose 200-800mg divided; maximum 800mg/day NR 546 Advanced Pharmacology  Psychosis-increase dose until symptoms are controlled; after 2 weeks reduce to lowest effective dose  Can improve in one week but may take several weeks for full effect on behavior  Tablet 10, 25, 50, 100, 200mg  Half-Life 8-33 hours  Phenothyazine  SXS-Dry mouth, pupil dilation, blurred vision, cog impair, constipation, urinary retention, tachycardia Mesoridazine-Low-off market due to dangerous side effects, including irregular heartbeat and QT prolongation. *Low potency meds require higher doses to achieve efficacy *Low potency meds have more anticholinergic, antihistaminic, and α 1 properties resulting in more sedation than higher potency meds. *High risk for developing hyperprolactinemia and EPS (negative symptoms aren’t affected by FGAs only positive symptoms) Neurolepsis is a term to describe antipsychotic medication effects on psychotic clients, with respect to cognition and behavior. Newer medications (SGA) do not necessarily have these same effects. Neurolepsis syndrome has three major features. Examine the image below to learn more about the PEA acronym.  Psychomotor slowing - extreme form of slowness or absence of motor movement (nigrostriatal pathway)  Emotional quieting - worsening of negative and cognitive symptoms (mesocortical pathways)  Affective indifference - worsening of affective symptoms (mesocortical pathway) Atypical antipsychotics (SGA) Developed to treat both positive (+) and (-) negative symptoms  SGAs are considered serotonin-dopamine antagonists, as they maintain D2 antagonism but also have simultaneous serotonin 5HT2A antagonism  Lower affinity for D2 and higher affinity for 5HT  Effective for treatment-resistant clients  Does not increase prolactin levels  Treats positive and negative symptoms  Lower risk of EPS Olanzapine-Schizophrenia- age 13 and older  Serotonin-Dopamine antagonist-reducing positive sxs; Antagonist actions at the 5HT2C receptor may contribute to efficacy for cognitive and affective sxs  *More weight gain and metabolic effects  *High metabolic risk  Highest risk for weight gain, blood dyscrasias, QT prolongation, cardiovascular disease, cerebrovascular effects, hyperglycemia, and *hyperprolactinemia  Most commonly used in pregnant women with least risk for congenital harm  Half-life 21-54 hours  Substrate for CYP450 1A2 and 2D6  Usual dose 1-20mg/d  Initial dose 5-10mg/d increase by 5mg/day once a week until desired efficacy  Max dose 20mg/d  MOA-  Special Comments: Best tolerated antipsychotic  AVOID IN PREGNANCY!  Avoid in older adults due to increased risk of cerebrovascular accident (CVA), cognitive decline, and death in persons with dementia and with dementia-related psychosis. Quetiapine-Acute schizophrenia in adults and aged 13-17  Serotonin-Dopamine antagonist, also a mood stabilizer  Most commonly used in pregnant women with least risk for congenital harm  Usual dose 400-800mg divided; maximum 800mg/day  Initial dose 25mg/BID, increase by 25-50 twice a day until efficacy reached  Tablet 25, 50, 100, 150, 200, 300, 400mg  Half-Life 6-7 hours  Substrate for CYP450 3A4  MOA-  Moderate metabolic risk  Low EPS risk  Risk of orthostatic hypotension, blood dyscrasias (neutropenia, leukopenia, and agranulocytosis), QT prolongation, weight gain, and renal and hepatic impairment  AVOID IN PREGNANCY!  BLACK BOX WARNING: Increased risk of suicidal ideation and suicidal behavior in adolescents/young adults during the initial 1-2 months of treatment  CAUTION: exercise caution in suspected alcohol withdrawal, stimulant intoxication, or anticholinergic intoxication.