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Samenvatting FARMACOLOGIE DEEL 2 $9.28   Add to cart

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Samenvatting FARMACOLOGIE DEEL 2

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Deze samenvatting is gebaseerd op "Deel 2: transmissie in het perifeer en autonoom zenuwstelsel" van de cursus farmacologie gedoceerd door prof. de Hoon en prof. Casteels met toevoeging van mijn notities uit de les. Met behulp van deze samenvatting slaagde ik in eerste zit met 17/20.

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  • July 27, 2023
  • 21
  • 2022/2023
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Farmacologie deel 2
TRANSMISSIE IN HET PERIFEER EN AUTONOOM ZENUWSTELSEL
ELLA COOMANS

,Inhoudsopgave

1 Cholinerge transmissie ...........................................................................................................................3
1.1 TOEPASSING: cannabis, alcohol, ecstacy, cocaine,… ............................................................................ 7
1.2 TOEPASSING: Glaucoom ..................................................................................................................... 10
1.3 TOEPASSING: behandeling luizen, schurft, teken ............................................................................... 10

2 Adrenerge transmissie ......................................................................................................................... 11
2.1 Activatie van adrenerge transmissie .................................................................................................. 11
2.2 Inhibitie van adrenerge transmissie ................................................................................................... 16
2.3 TOEPASSING: geneesmiddelen gebruikt bij obesitas en centrale stimulantia .................................... 19

3 Dopaminerge transmissie .................................................................................................................... 21

4 Serotonerge transmissie ...................................................................................................................... 21




2

, Motorisch ZS: neuromusculaire junctie, Ach op nicotineR

Autonoom ZS: neuro-effectorjunctie
a) Parasympatisch: preganglionair Ach op nicotineR, post- Ach op muscarineR, uitsluitend
PS: m. constrictor pupillae, m. ciliaris, GI-klieren, traanklieren, bronchiale gladde spieren
b) Orthosympatisch: preganglionair Ach op nicotineR, post- NA of Ach op muscarineR,
uitsluitend OS: zweetklieren, pilomotorspieren, bloedvaten, nier, m. dilatator pupillae,
skeletspieren, bijniermerg (enkel postganglion)
c) Enterisch: PS ganglia en preganglionaire vezels, intrinsieke neuronen in intramurale
plexus darmwand, OS postganglionaire vezels
orthosympatisch ZS parasympatisch ZS
outflow thoracolumbaal craniosacraal
cellichamen thoracaal mes/med.oblong/sacraal
preggl neuron kort lang
postggl neuron lang kort
ganglia paravertebraal dicht bij effectororgaan
NT in autonoom ggl ACh ACh
NT thv NE NA* ACh
exit preggl neuron T1-L2 III, VII, IX, X en S2-S4

Activiteit preganglionaire vezels geregeld door neerdalende banen vanuit hersenen

Receptoren:
agonist antagonist
para (NE) muscarine* atropine
ganglia nicotine(*) ggl.blockers
NMJ nicotine* curare

1 Cholinerge transmissie
Muscarinereceptoragonisten
Acetylcholine Korte halfwaardetijd
Indicatie: lokaal in oogheelkunde à miosis
Pilocarpine Langere halfwaardetijd
Tertiair amine à door BBB
Indicatie: mioticum en bij extreme monddroogte door onvoldoende
speekselsecretie
Carbachol Muscarine- en nicotineR
Indicatie: mioticum
Betanechol Indicatie: bij postoperatieve urineretentie, blaasatonie bij
neurologische aandoeningen




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