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Samenvatting FARMACOLOGIE DEEL 4 $11.00   Add to cart

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Samenvatting FARMACOLOGIE DEEL 4

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Deze samenvatting is gebaseerd op "Deel 4: geneesmiddelen van het cardio-vasculair stelsel" van de cursus farmacologie gedoceerd door prof. de Hoon en prof. Casteels met toevoeging van mijn notities uit de les. Met behulp van deze samenvatting slaagde ik in eerste zit met 17/20.

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  • July 27, 2023
  • 24
  • 2022/2023
  • Summary
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Farmacologie deel 4
GENEESMIDDELEN VAN HET CV-STELSEL
ELLA COOMANS

,Inhoudsopgave

1 Diuretica ................................................................................................................................................3

2 Antihypertensiva ...................................................................................................................................6

3 Hartfalen ...............................................................................................................................................9

4 Ischemisch hartlijden ........................................................................................................................... 12

5 Hyperlipidemie .................................................................................................................................... 14
5.1 Hypolipemiërende farmaca ................................................................................................................ 14

6 Bloedstolling ........................................................................................................................................ 17
6.1 Anticoagulantia .................................................................................................................................. 17
6.2 Trombocytaggregatieremmers – anti-aggregantia ............................................................................ 20
6.3 Fibrinolytische stoffen/trombolytica .................................................................................................. 20
6.4 Indicaties van anticoagulantia, anti-aggregantia en trombolytica .................................................... 21

7 VKF ...................................................................................................................................................... 24




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, 1 Diuretica
Koolzuuranhydrase-inhibitoren
Product Acetazolamide (sulfonamide-derivaten)
Werking




à Systemische acidose en meer alkalische urine bij lang gebruik
à Diuretische efficiëntie neemt af na enkele dagen
Farmacokinetiek Peroraal
Max effect na 2 uur
Effect 12 uur lang
Renale excretie
Indicaties 1) Openhoek-glaucoom
2) Alkalinisatie urine
3) Metabole alkalose tgv diureticagebruik bij iemand met ernstig
hartfalen (kunnen geen zout gebruiken hiervoor)
4) Acute hoogteziekte: productie en pH CSV verlagen
Bijwerkingen - Verergert metabole/respiratoire acidose
- Nierstenen (calciumzouten minder oplosbaar is alkalische urine)
- Hypokaliëmie
- Meer ammoniak in systeemcirculatie à kans encefalopathie
- Hoge dosis: slaperigheid en paresthesieën
- Zelden overgevoeligheidsreacties

Thiaziden
Producten Hydrochloorthiazide, chloorthalidon, indapamide
Werking Blokkeren Na/Cl-symporter in distale kronkelbuis
à verhogen K-secretie à K-depletie à alkalose
Chronische toediening vermindert Ca-excretie
Farmacokinetiek Peroraal
Bij excretie in competitie met urinezuur
Indicaties 1) Hypertensie bij GFR > 30 ml/min: diuretisch en zwak
vasodilaterend, tegelijk zoutbeperking (meer effect en minder K-
verlies)
2) Onderhoud bij congestief hartfalen (niet als GFR < 30 ml/min)
3) Ernstig resistent oedeem
4) Nefrolithiase tgv hypercalciurie (bij tegelijk zoutbeperking)


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