PK Final Exam 2023 with 100% correct answers

A patient was admitted to the hospital because of acute myocardial infarction. After stabilizing his condition, the patient was given an IV loading dose of 150 mg of lidocaine followed by a constant rate IV infusion of 2 mg/min. What is the rate of lidocaine elimination at the steady-state? 2 mg/min A patient has reduced kidney function when compared to a normal patient. If the infusion rate for a normal patient is used to infuse the impaired patient with a drug, the Cpss for the impaired patient will be: A. smaller than the normal patient B. the same as the normal patient C. larger than the normal patient D. Infusions do not show a steady state plasma level C. larger than the normal patient A graph below shows a pharmacokinetic profile of a drug given as an IV infusion. The phase 1 on the curve corresponds to which of the following pharmacokinetic processes? A. Elimination B. Steady-state C. Fluctuation D. Accumulation E. Absorption D. Accumulation A drug is administered by IV bolus administration. Semi-log plots of Cp vs t are prepared for several different doses (X0). It is observed that semi-log plots are linear at low doses but are non-linear at high doses. These plots indicate: A. A one compartment model applies to this drug. B. A two compartment model applies to this drug. C. The drug is excreted by passive diffusion. D. this drug exhibits non-linear pharmacokinetics. E. It cannot be determined which of the above models applies. D. this drug exhibits non-linear pharmacokinetics. Which of the following correctly explains the "principle of superposition'? A. Multiple subsequent doses have an additive effect on the total plasma concentration. B. Multiple subsequent doses have no effect on the total plasma concentration. C. Discrete single doses have an additive effect on the total plasma concentration. D. Multiple subsequent doses have an additive effect on the volume of distribution. A. Multiple subsequent doses have an additive effect on the total plasma concentration.