PK Exam 1 2023 with 100% correct answers

Biopharmaceutics considers interrelationships of -physiochemical properties of drug -dosage form -route of administration Pharmacokinetics -what the body does to the drug -science of kinetics of drug absorption; distribution and elimination and corresponding pharmacological, the toxicological and clinical response in animals and man Clinical Pharmacokinetics application of pharmacokinetics methods to drug therapy. pharmacodynamic relationship between drug concentration at site of action and a pharmacological response which could include biochemical and physiology effects that influence interaction of drug with receptor drug exposure refers to dose and concentration of drug in body drug response direct measure of pharmacologic response usually endpoints or biomarkers Why are drug concentrations more often measured in plasma than whole blood or serum? Drug is in plasma, not whole blood or serum. Plasma has proteins that bind to unbound drug. Whole blood has too many components Serum must clot first and can potentially lose drug by lysing Bound drug when drug is bound to protein Unbound drug Drug is not bound to protein Parent drug original form of drug when administered (unchanged)