NR 546 Antipsychotics Table Week 3 Assignments. Drug name Indication Target symptoms: state if positive or negative effect Potency (if noted. receptor occupancy if noted) Neurotransmitter(s) affected Half-life (T1/2), metabolism (CYP 450 enzyme) Notable side effects (associate to pathway or...
NR 546 Antipsychotics Table Week 3
Assignments latest 2023
, Drug name Indication Half-life (T1/2), Notable side effects (associate to pathway or NT)
Target symptoms: state if positive or negative effect metabolism
Potency (if noted. receptor occupancy if noted ) (CYP 450
Neurotransmitter(s) affected enzyme)
Typical antipsychotics (conventional)
Haloperidol Blocks dopamine 2 receptors, reducing positive Decanoate Acute blockade of dopamine 2 receptors in the
symptoms of psychosis and possibly combative, half-life striatum can cause drug-induced parkinsonism,
explosive, and hyperactive behaviors Blocks dopamine approximately dystonia, or akathisia
2 receptors in the nigrostriatal pathway, improving tics 3 weeks Oral Chronic blockade of dopamine 2 receptors in the
and other symptoms in Tourette’s syndrome. half-life striatum can cause tardive dyskinesia
approximately By blocking dopamine 2 receptors in the pituitary,
12–38 hours it can cause elevations in prolactin
By blocking dopamine 2 receptors excessively in
the mesocortical and mesolimbic dopamine
pathways, especially at high doses, it can cause
worsening of negative and cognitive symptoms
(neuroleptic-induced deficit syndrome).
Blocking alpha 1 adrenergic receptors can cause
dizziness, hypotension, and syncope
Thioridazine Blocks dopamine 2 receptors, reducing positive Metabolized Acute blockade of dopamine 2 receptors in the
symptoms of psychosis by CYP450 2D6 striatum can cause drug-induced parkinsonism,
dystonia, or akathisia.
Chronic blockade of dopamine 2 receptors in the
striatum can cause tardive dyskinesia
By blocking dopamine 2 receptors in the pituitary,
it can cause elevations in prolactin
By blocking dopamine 2 receptors excessively in
the mesocortical and mesolimbic dopamine
pathways, especially at high doses, it can cause
worsening of negative and cognitive symptoms
(neuroleptic-induced deficit syndrome)
Blocking muscarinic cholinergic receptors can
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller TrizaEducator. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $15.52. You're not tied to anything after your purchase.
