101
Some enzymes will catalyze the flipping of the phospholipid membrane
Process of oxidizing fat: beta-oxidation
16 carbon fat produces 7NADH molecules
Cell division
MreB- actin homologue: drives the segregation of replication origins in
bacteria replication. Its genetic sequence is different from that of humans but
they have a similar structure.
During metaphase where the kinetochore attaches to the centromere of the
chromosome, cohesion proteins keep the chromatids bound together.
Prometaphase (pre-metaphase but after prophase): the chromosomes move
around as they are attached to the microtubules which can move around due
to their motor proteins as they grow and contract.
Cyclins: these fluctuate during the cell cycle.
CDK (Cyclin-dependent kinases): A kinase is a protein that phosphorylates a
protein. It becomes active when bound to a cyclin and when phosphorylated
by the correct group of phosphates
PROTEIN WORLD
(Lecture 3)
Haemoglobin has a tetramer structure which was mapped by Max Perutz
(1914-2002) who shared the Nobel prize with John Kendrew in 1962. This is
the same year Watson and Crick received their Nobel prize for DNA helix
structure.
Serum transferrin is a bilobal protein. The two lobes are connected by a
peptide. It prevents the precipitation of Fe(III) by taking up the extra iron in
the bloodstream. Some iron is taken up by bacteria in the blood for their
survival but serum transferrin has a high affinity for this and takes it up
before the bacteria does prevent the survival of bacteria.
Serum transferrin delivers Iron throughout the body via a transferrin
receptor.
Upon binding of iron, the bilobal shape (the domains) come together and
trap Fe like a Venus flytrap.
TRANSPORT- TERRY
Anything lipid-soluble can gain entry into the bilayer.
Potassium leak channel; open pore leaks potassium.
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