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Samenvatting mindmaps farmacologie colleges
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Mindmaps over de colleges van farmacologie
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, hoorcollege^ (
z
awt
Pken Pal
bktijd gaat over concentratie relatie
tägd tijd
^
bd gaat over concentratie effect relatie
eftest
tügd
Er wordt gebruik gemaakt wan modellen omn te omschrijven
wat er gebeurden te voorspellen
.
on afhankele variabele : bijr tijd ( concCod
]?
x-waarde,
PKJ
afhankele variabele : 4- bijr concCPK ,
effet CPBJ
waarde,
primaire parameters o
Birect gelinktaan lichaams processen
x
te berekenen op basis van conc curve PK
-tijd
Zoals CL Vd Emax ECso
:
,
,
,
secumdaire Barameters o
afgeleiat van
^
zoals Cmax K , tmax t
12
,
,
.
Emax Ey
posis e E
.
-et
C =
r
=
EC C
.
en
4
5o44
ce
c conc W E
=effect
=
=K
Ls
eliminatie snelheidsconstante stijd
beschrijvend compartment models fysiologiscN
secundaire pk para primaire pK paramete physilogical paramelen
Cmax Vd Lever functie
tmax Cl Enzyrn activiteit
Eliminatie half waarde bloedflow
tijd
eiwit binding
herhaling van adme î
, herhaling van orde processen
·orde
afname lineair
CP=
D porde
afname exponentieel
=
L
by infuus Ro of IV-bolus, adme
PK relaties
ir-Bolus
h,a3Seriee n
extravasculair
depot
. Losse en
t
E
·
·meieen
Farmacopynamiek
prugactie ->
op targely receptor
Drug effect -> observeerbare consequentie
Drug response -> klinische witkomst
W
Gigand Parameters
affiniteit
sospycoe
"de neiging van een geneesmiddel om receptor te binden"
eigenschap van
-
een geneesmiddel. Ka wordtuitgedrukt
in conc
waard;ie vergeliken
ze kunt per geneesmiddel
potency/potentie
"de conc die nodig is voor gewenst effect"
hiervoor EC50
wordt gebruikt. Hoe lager EC50 hoe hogere potency
er is dan minder gum nodig om so van {max te krijgen
Effectiviteit
"het vermogen van agonist -
receptor complex
om effectop te wekken"
"
verschiltper weefsel en cel
specificiteit
hoe specifiek selectiefde binding verloopt"
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