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Exam (elaborations)

PA (ASCP) Certification Exam Questions & Answers 2023/2024

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PA (ASCP) Certification Exam Questions & Answers 2023/2024 Hypertrophy - ANSWER-Increased cell and organ size, often in response to increased workload: induced by mechanical stress and by growth factors; occurs in tissue incapable of cell division Hyperplasia - ANSWER-Increased cell numbers...

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  • September 7, 2023
  • 32
  • 2023/2024
  • Exam (elaborations)
  • Questions & answers
  • PA Certification
  • PA Certification
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PA (ASCP) Certification Exam Questions
& Answers 2023/2024

Hypertrophy - ANSWER-Increased cell and organ size, often in response to increased workload: induced
by mechanical stress and by growth factors; occurs in tissue incapable of cell division



Hyperplasia - ANSWER-Increased cell numbers in response to hormones and other growth factors;
occurs in tissues whose cells are able to divide



Atrophy - ANSWER-Decreased cell and organ size, as a result of decreased nutrient supply or disuse:
associated with decreased synthesis and increased proteolytic breakdown of cellular organelles



Metaplasia - ANSWER-Change in phenotype of differentiated cells, often a response to chronic irritation
that makes cells better able to withstand the stress



Hypoxia - ANSWER-Oxygen deficiency which interferes with aerobic oxidative respirations and is an
extremely important and common cause of cell injury and death



Ischemic - ANSWER-Loss of blood supply in a tissue due to impeded arterial flow or reduced venous
drainage



Coagulative necrosis - ANSWER-A form of tissue necrosis in which the component cells are dead but the
basic tissue architecture is preserved for at least several days



Liquefactive necrosis - ANSWER-A form of necrosis seen in focal bacterial or occasionally fungal
infections because microbes stimulate the accumulation of inflammatory cells and the enzymes of
leukocytes digest the tissue



Caseous necrosis - ANSWER-A form of necrosis encountered most often in foci of tuberculous infections

,Fat necrosis - ANSWER-Term referring to focal areas of fat destruction, typically resulting from release of
activated pancreatic lipases into the peritoneal cavity



Fibrinous necrosis - ANSWER-A special form of necrosis usually seen in immune reactions involving blood
vessels



Autophagy - ANSWER-Lysosomal digestion of the cell's own components



Apoptosis - ANSWER-A pathway of cell death that is induced by a tightly regulated suicide program in
which the cells destined to die activate enzymes capable of degrading the cells own nuclear DNA



Steatosis (fatty change) - ANSWER-Refers to any abnormal accumulation of triglycerides within
parenchymal cells It is most often seen in the liver



Dystrophic calcification - ANSWER-Depositions of calcium at sites of cell injury and necrosis



Metastatic calcification - ANSWER-Deposition of calcium in normal tissues, caused by hypercalcemia
(usually a consequence of parathyroid hormone excess)



Inflammation - ANSWER-A protective response intended to eliminate the initial cause of cell injury as
well as the necrotic cells and tissues resulting from the original insult



Acute inflammation - ANSWER-A rapid response to injury or microbes and other foreign substance that is
designed to deliver leukocytes and plasma proteins to sites of injury



Serous inflammation - ANSWER-Fluid in a serous cavity



Serous inflammation is marked by fluid transudates, reflecting moderately increased vascular
permeability. Such accumulations in the peritoneal, pleural, and pericardial cavities are called effusions;



Effusion - ANSWER-Fluid in a serous cavity ,

,Fibrinous inflammation - ANSWER-Inflammation occurring as a consequence of more severe injuries,
resulting in greater vascular permeability that allows large molecules (such as fibrinogen) to pass the
endothelial barrier



Abscess - ANSWER-Focal collections of pus that may be caused by seeding of pyogenic organisms into a
tissue or by secondary infections of necrotic foci



Ulcer - ANSWER-A local defect or excavation of the surface of an organ or tissue that is produced by
necrosis of cells and sloughing of inflammatory necrotic tissue



Cytokines - ANSWER-Polypeptide products of many cell types that function as mediators of inflammation
and immune responses



Chronic inflammation - ANSWER-Prolonged inflammation in which active inflammation, tissue injury, and
healing proceed simultaneously



Granulomatous inflammation - ANSWER-A distinctive pattern of chronic inflammation characterized by
aggregates of activated macrophages that assume an epithelioid appearance



Repair - ANSWER-The restoration of tissue architecture and function after an injury



Regeneration - ANSWER-The process of replacing damaged tissue components and essentially returning
to a normal state



Fibrosis - ANSWER-The extensive deposition of collagen that occurs in the lungs, liver, kidney and other
organs as a consequence of chronic inflammation



Angiogenesis - ANSWER-A critical process in healing at sites of ischemia where a preexisting vessel sends
out capillary sprouts to produce new vessels



Keloid - ANSWER-A prominent raised scar caused by the accumulation of exuberant amounts of collagen

, Edema - ANSWER-Significant increased fluid in the interstitial tissue spaces



Anasarca - ANSWER-Severe and generalized edema with profound subcutaneous tissue swelling



Hyperemia - ANSWER-A local increase in blood volume that is an active process from augmented blood
flow due to arteriolar dilation



Congestion - ANSWER-A local increase in blood volume that is a passive process resulting from impaired
venous return out of a tissue



Hematoma - ANSWER-The accumulation of blood confined within a tissue after a hemorrhage



Normal hemostasis - ANSWER-A tightly regulated process that maintains blood in a fluid, clot-free state
in normal vessels while inducing the rapid formation of a localized hemostatic plug at the site of vascular
injury



Thrombosis - ANSWER-Blood clot (thrombus) formation in uninjured vessels or thrombotic occlusion of a
vessel after relatively minor injury



Lines of Zahn - ANSWER-The grossly and microscopically apparent lamination in a thrombi representing
pale platelet and fibrin layers alternating with darker erythrocyte-rich layers



Embolism - ANSWER-A detached intravascular solid, liquid, or gaseous mass that is carried by the blood
to a site distant from its point of origin



Infarct - ANSWER-An area of ischemic necrosis caused by occlusion of either the arterial supply or the
venous drainage in a particular tissue



Shock - ANSWER-The final common pathway for a number of potentially lethal events that causes
systemic hypoperfusion due to either reduced cardiac output or reduced circulating blood volume

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