ASCP Hematology Review Exam
Questions & Answers 2023/2024
Name the locations of active marrow in adults: - ANSWER-sternum, skull, ribs, pelvis, vertebrae
Where does hematopoiesis take place during the first 2 months of gestation? - ANSWER-yolk sac
Where does the majority of hematopoiesis take place during the 2nd through 7th month of gestation? -
ANSWER-spleen
When does the bone marrow take over hematopoiesis? - ANSWER-after birth
What are the stages in order of the erythrocyte lineage? - ANSWER-(1)rubriblast, (2)prorubricyte,
(3)rubricyte, (4)metarubricyte, (5)reticulocyte, (6)erytrocyte
What are the stages in order of the granulocyte (neutrophil, eosinophil, basophil) lineage? - ANSWER-
(1)myeloblast, (2)promyelocyte, (3)myelocyte, (4)metamyelocyte, (5)band, (6)segmented (7)eos/baso
What are the stages in order of the macrophage lineage? - ANSWER-(1)monoblast, (2)promonocyte,
(3)monocyte, (4)macrophage
What are the stages in order of the platelet lineage? - ANSWER-(1)megakaryoblast,
(2)promegakaryocyte, (3)megakaryocyte, (4)platelet
What are the stages in order of the lymphocyte lineage? - ANSWER-(1)lymphoblast, (2)prolymphocyte,
(3)lymphocyte
Which growth factors stimulate the erythrocyte lineage? - ANSWER-GM-CSF, EPO, IL-3
,Which growth factors stimulate the granulocyte lineages? - ANSWER-GM-CSF, IL-3
Which growth factors stimulate the platelet lineage? - ANSWER-GM-CSF, IL-3, TPO
Which growth factors stimulate the lymphocyte lineage? - ANSWER-IL-2, IL-4, IL-6, IL-7
Which protein functions in the transport of Fe? - ANSWER-transferrin
What is the major storage form of Fe? - ANSWER-ferritin
What is the long-term (H20) insoluble Fe storage form called? - ANSWER-hemosiderin
Excess Iron is stored where? What does this cause? - ANSWER-tissues and body organs, hemosiderosis,
hemochromatosis
Porphyrias are attributed to? - ANSWER-excessive formation of porphrins due to blockages in any
enzymatic step in the heme synthesis pathway.
Red or port wine colored urine can be seen in which condition related to the build up of heme
precursors? - ANSWER-porphyria
Neuropsychiatirc symptoms are seen when a build up of which precursors occurs? - ANSWER-early
precursors (Delta-aminolevulinic acid/Porphobilinogen)
Cutaneous symptoms such as photo-sensitivity and facial hair are seen when a build up of which
precursors occurs? - ANSWER-later precursors (uroporphyrinogen/coproporphyrinogen,
protoporphyrin/heme)
Synthesis of heme requires what two components? - ANSWER-iron, protoporphyrin
, What are the heme precursors in order of synthesis? - ANSWER-(1)delta-aminolevulinic acid,
(2)porphobilinogen, (3)uroporphyrinogen, (4)coproporphyrinogen, (5)protoporphyrin, (6)heme
What type of hemoglobin is seen primarily in newborns? - ANSWER-Hgb F
What type of hemoglobin is seen primarily in adults? - ANSWER-Hgb A2
What type of hemoglobin is rarely seen in adults as well as newborns? - ANSWER-Hgb A
What hemoglobin types are seen in embryos but not in adults or newborns? - ANSWER-gower I, gower
II, portland
All non-embryonic hemoglobin types are comprised of what type of globin chain? - ANSWER-alpha
Hemoglobin A2 is composed of what types of globin chains? - ANSWER-alpha, beta
Hemoglobin A is composed of what types of globin chains? - ANSWER-alpha, delta
Hemoglobin F is composed of what types of globin chains? - ANSWER-alpha, gamma
Multiple transfusions can cause what kind of shift in the hemoglobin-oxygen dissociation curve? -
ANSWER-left shift
An increase in hemoglobin F can cause what kind of shift in the hemoglobin-oxygen dissociation curve? -
ANSWER-left shift
A left shift in the hemoglobin-oxygen dissociation curve causes what changes in the following
substances: CO2, pH, 2,3-DPG? - ANSWER-increased pH, decreased CO2, decreased 2,3-DPG
A right shift in the hemoglobin-oxygen dissociation curve causes what changes in the following
substances: CO2, pH, 2,3-DPG? - ANSWER-decreased pH, increased CO2, increased 2,3-DPG
