7. Free radical and ROS: E. normal byproduct of ATP production, will
overwhelm the mitochondria- exhaust intracellular antioxidants
P. lipid peroxidation, damage proteins, fragment DNA
C.M. development in Alzheimer's, heart disease, Parkinson's disease,
Amyotrophic Lateral Sclerosis
8. Ethanol: E. mood altering drug, long term effects on liver and
nutritional status
P. metabolized by liver, generates free radicals
C.M. CNS depression, nutrient deficiencies-Mag, Vit B6, thiamine, PO4,
inflamma- tion and fatty infiltration of liver, hepatomegaly, leads to
2/
, liver failure irreversible
9. Oncosis: Na and H2O enter cell and cause swelling. Organ increases
in weight, becomes distended and pale. Associated with high fever,
hypocalcemia, certain infections
10.Fatty Infiltration: intracellular accumulation of lipids in the liver
liver fails to metabolize lipids. usually from ETOH or high fat diet. can
lead to cirrhosis
3/
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