Team based learning and practice exam questions and answers
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Course
Advanced Molecular Biology (NWIBB017C)
Institution
Radboud Universiteit Nijmegen (RU)
This 14 page long document includes the questions and answers of the team based learning exercises (12), application cases (3), and a practise exam (4) of the course Advanced Molecular Biology (Radboud University NWI-BB017C 6EC). My grade = 8,0.
What is the main difference between mutation in a cis regulatory DNA element vs mutation in a
transcription factor gene?
Question 1 options:
Mutation in the DNA element can only result in loss of expression, while mutation in TFs can lead to both up an
downregulation.
Point mutation in DNA elements always leads to gene expression change, while similar mutation in TF might be
"silent".
Inversion in the promoter region seldom influence its function, while inversion of the coding sequence always
results in loss of function.
Mutation in the DNA elements only effects a single or few genes, while mutation in TF effects the expression of
many genes.
Question 2 (1 point)
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Heterochromatin formation is key to long term silencing of genes. Which of the following canNOT
explain heterochromatin formation?
Question 2 options:
expression of a noncoding RNA that recruits the PRC2 complex (= guided to specific regions to noncoding RNA)
phosphorylation of histones during S-phase (releasing heterochromatin formation)
binding of a DNA-binding protein that recruits a histone deacetylase enzyme (creates repressive environment)
deletion of a boundary element and undesired spreading of heterochromatin (boundary element can spread op
or closed chromatin, boundary element important in heterochromatin formation)
Question 3 (1 point)
1
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Signal transduction pathways often lead to phosphorylation and activation of kinases (such as ERK)
and eventual activation of transcriptional regulators (such as Fos). If you detect high level of ERK
phosphorylation in a tumor sample which of the following hypotheses is most likely?
Question 3 options:
tumor cells carry a loss of function mutation in the kinase domain of MAPK
tumor cells carry a mutation in FOS that leads to higher proliferation of the tumor cells and in turn higher level
ERK phosphorylation
tumor cells secrete increased level of cytokines, that in turn increases ERK phosphorylation in other tumor cells
tumor cells carry a mutation in the growth factor receptor, that makes it constitutively active even in absence o
the ligand
Question 4 (1 point)
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Why is a cap added to mRNA, but not to tRNA or rRNA?
Question 4 options:
2
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