Summary
Samenvatting Naslag Nucleaire geneeskunde MB1 Minor
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Alle zelfstudie van de MB1 minor
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Definitie plagiaat:VOORBLAD VERSLAG/ RAPPORTAGE
Onder plagiaat wordt verstaan het overnemen van andermans werk en dat laten doorgaan
voor eigen werk. Het geheel of gedeeltelijk overnemen van teksten van andere auteurs
zonder plaatsing van aanhalingstekens en nauwkeurige bronvermelding in een werkstuk of
scriptie valt hieronder. Ook het achterwege laten van bronvermeldingen bij informatie die
niet letterlijk is overgenomen, maar wel duidelijk gebaseerd is op teksten of ideeën van
anderen, is plagiaat.
Verklaring student:
Ik heb de bovenstaande definitie van plagiaat zorgvuldig gelezen. Door inleveren van dit product, verklaar ik
dat dit mijn eigen werk is en ik mij niet schuldig heb gemaakt aan plagiaat.
MBRT
Naam:
Studentnummer:
Groep: MB1 Groep B
Inleverdatum: 16-01-2022
Verslag/rapportagenaam: NG-naslag
En code: 2916APM02A
(Code zoals in toetsplan/OER)
Aanpassen indien anders Kans:1
1
,Inhoudsopgave
1 Principe PET ............................................................................................................................................. 6
1.1 Fysische eigenschappen straling PET ..................................................................................................... 6
1.2 Wijze van detectie straling .................................................................................................................... 6
1.3 Soorten scans ......................................................................................................................................... 7
1.4 Soorten pathologieën ............................................................................................................................ 8
2 PET-Apparatuur ....................................................................................................................................... 9
2.1 Meting ................................................................................................................................................. 10
2.2 TOF ....................................................................................................................................................... 11
2.3 Reconstructies...................................................................................................................................... 11
2.4 CT ......................................................................................................................................................... 12
3 Meet- en scantechnieken ....................................................................................................................... 13
3.1 Line of response ................................................................................................................................... 13
3.2 Time Of Flight ...................................................................................................................................... 13
3.3 Acquisitieparameters ........................................................................................................................... 14
3.3.1 Coupedikte ...................................................................................................................................... 14
3.3.2 Tafelposities .................................................................................................................................... 14
3.3.3 Matrix .............................................................................................................................................. 14
3.3.4 Energiepiek en energiewindow ....................................................................................................... 14
3.3.5 Teltijd............................................................................................................................................... 14
3.4 Verschillende foutmeldingen ............................................................................................................... 14
3.4.1 Trues ................................................................................................................................................ 14
3.4.2 Line of respons ................................................................................................................................ 15
3.4.3 Singles ............................................................................................................................................. 15
3.4.4 Escapes ............................................................................................................................................ 15
3.4.5 Randoms.......................................................................................................................................... 15
3.4.6 Scatters ............................................................................................................................................ 15
3.4.7 Detectie ........................................................................................................................................... 15
3.5 Reconstructies...................................................................................................................................... 16
3.5.1 2D .................................................................................................................................................... 16
3.5.2 3D .................................................................................................................................................... 16
3.5.3 Iteratief ............................................................................................................................................ 16
3.5.4 MLEM .............................................................................................................................................. 16
3.5.5 OSEM ............................................................................................................................................... 16
3.5.6 MIP .................................................................................................................................................. 16
3.6 Verzwakking ........................................................................................................................................ 17
3.7 SUV-waarde ......................................................................................................................................... 17
4 FDG-Onderzoeken.................................................................................................................................. 19
4.1 Indicaties FDG PET-CT .......................................................................................................................... 19
4.2 Voorbereiding FDG-PET-CT .................................................................................................................. 19
4.3 Verloop van een FDG-onderzoek ......................................................................................................... 21
4.4 Gevolgen van een slechte voorbereiding ............................................................................................. 23
4.4.1 Glucoseconcentratie ....................................................................................................................... 23
2
, 4.4.2 Glucose in de spieren ...................................................................................................................... 23
4.4.3 Glucose uptake door bruin vet activatie ......................................................................................... 23
4.4.4 Paraversale prikincidenten .............................................................................................................. 24
5 PET-CT combinatieonderzoeken ............................................................................................................ 25
5.1 Bouw PET-CT ........................................................................................................................................ 25
5.2 Voordelen combinatieonderzoek PET-CT ............................................................................................. 26
5.3 Globale uitvoering combinatieonderzoek ............................................................................................ 26
5.4 PET-CT beelden met uitleg ................................................................................................................... 28
5.4.1 18F-FDG ............................................................................................................................................ 28
5.4.2 18F-DOPA.......................................................................................................................................... 28
5.4.3 82Rb .................................................................................................................................................. 29
6 Cyclotron principe en radionuclide productie ........................................................................................ 30
6.1 Bouw en werking cyclotron.................................................................................................................. 30
6.2 Fysische aspecten en productie van de radionucliden ......................................................................... 30
6.2.1 11C .................................................................................................................................................... 30
6.2.2 13N ................................................................................................................................................... 31
6.2.3 15O ................................................................................................................................................... 32
6.2.4 18F .................................................................................................................................................... 32
6.2.5 82Rb .................................................................................................................................................. 33
7 Radiofarmaca lijst .................................................................................................................................. 34
8 Beeldherkenning .................................................................................................................................... 40
9 Artefacten .............................................................................................................................................. 44
9.1 Artefacten ontstaan door de apparatuur ............................................................................................ 44
9.1.1 Detectorartefact .............................................................................................................................. 44
9.1.2 Ringartefact ..................................................................................................................................... 44
9.1.3 Scatterartefact ................................................................................................................................ 44
9.1.4 Truncationartefact .......................................................................................................................... 45
9.2 Artefact veroorzaakt door de patiënt zelf............................................................................................ 46
9.2.1 Actief ............................................................................................................................................... 46
9.2.2 Passief ............................................................................................................................................. 47
9.3 Artefacten door de software................................................................................................................ 47
9.3.1 FBP-artefact ..................................................................................................................................... 47
9.3.2 Geen axiale correctie....................................................................................................................... 48
9.3.3 Geen verzwakkingscorrectie ........................................................................................................... 48
9.3.4 Ondercorrectie door armen ............................................................................................................ 48
9.3.5 Overcorrectie .................................................................................................................................. 49
9.3.6 Misalignment................................................................................................................................... 49
9.4 Artefacten door externe factoren ........................................................................................................ 49
9.4.1 Artefact veroorzaakt door medisch personeel ................................................................................ 49
9.4.2 Artefact veroorzaakt door de patiënt ............................................................................................. 49
9.4.3 Ademhalingsartefact ....................................................................................................................... 50
9.4.4 Bruin vet artefact ............................................................................................................................ 50
9.5 Opdracht 2 ........................................................................................................................................... 51
10 Stralingsveiligheid PET/CT ................................................................................................................. 54
10.1 PET- en CT ............................................................................................................................................ 54
3
, 10.2 Productie van PET nucliden .................................................................................................................. 55
10.3 Transport ............................................................................................................................................. 56
10.4 Voorbereiding ...................................................................................................................................... 56
10.5 Toediening ........................................................................................................................................... 57
10.6 Tijdens het onderzoek .......................................................................................................................... 57
10.7 Basisprincipe bescherming .................................................................................................................. 57
10.8 Dosimetrie ........................................................................................................................................... 57
11 Casuspatiënten stage ......................................................................................................................... 58
11.1 Thom .................................................................................................................................................... 58
11.1.1 Vraagstelling ............................................................................................................................... 58
11.1.2 Voorbereiding ............................................................................................................................. 58
11.1.3 Acquisitie parameters ................................................................................................................. 59
11.1.4 Reconstructie .............................................................................................................................. 60
11.1.5 Beeldherkennig ........................................................................................................................... 62
11.1.6 Het verslag .................................................................................................................................. 62
11.2 Merel ................................................................................................................................................... 66
11.2.1 Vraagstelling ............................................................................................................................... 66
11.2.2 Voorbereiding ............................................................................................................................. 67
11.2.3 Acquisitieparameters .................................................................................................................. 67
11.2.4 Beeldherkenning ......................................................................................................................... 68
11.2.5 Pathologie ................................................................................................................................... 68
11.3 Noa ...................................................................................................................................................... 69
11.3.1 Casus ........................................................................................................................................... 69
11.3.2 Voorbereiding patiënt ................................................................................................................. 69
11.3.3 Aquisitieparameters.................................................................................................................... 69
11.3.4 Uitvoering onderzoek en onderzoekstechniek ........................................................................... 70
11.3.5 Beeldherkenning, anatomie en pathologie................................................................................. 70
11.4 Shivam ................................................................................................................................................. 72
12 Learnerreport stage ........................................................................................................................... 74
12.1 Thom .................................................................................................................................................... 74
12.1.1 Voorbereiding van de patiënt ..................................................................................................... 74
12.1.2 Acquisitieparameters .................................................................................................................. 74
12.1.3 Uitvoering onderzoek en onderzoekstechniek ........................................................................... 75
12.1.4 Werking apparatuur .................................................................................................................... 75
12.1.5 Uitwerkingen van de beeldgegevens .......................................................................................... 75
12.2 Merel ................................................................................................................................................... 77
12.2.1 Voorbereiding patiënt ................................................................................................................. 77
12.2.2 Acquisitieparameters .................................................................................................................. 77
12.2.3. Uitvoering onderzoek en onderzoekstechniek ........................................................................... 78
12.2.4 Werking apparatuur .................................................................................................................... 78
12.2.5 Uitwerkingen van de beeldgegevens .......................................................................................... 78
12.3 Noa ...................................................................................................................................................... 79
12.3.1 Voorbereiding patiënten ............................................................................................................. 79
12.3.2 Acquisitie parameters ................................................................................................................. 79
12.3.3 Uitvoeren onderzoek en onderzoekstechniek ............................................................................ 79
12.3.4 Werking apparatuur .................................................................................................................... 80
12.3.5 Uitwerking beeldgegevens.......................................................................................................... 80
12.4 Shivam ................................................................................................................................................. 81
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