2.2.1 Zonula occludens (tight junction)
● Structuur
→ als gordel rond cel
→ op bpd plaatsen
→ puntvormige contacten tss buitenbladen vn celmembraan vn naburige cellen
- integrale proteïnen vn celmembraan (globulaire eiwitten)
○ vn speciale soort
○ tot aaneensluitende richels of kannen aaneengekit
→ plasticiteit
- intramembraneuze verplaatsbaarheid vn globulaire proteïnen in vl lipidenlaag
→ netwerk vn richels
- dichte epithelen (vb. urineblaas)
- lekke epithelen: minder (vb. bijniertubuluscellen)
○ bij bpld omstandigheden: ‘dichte’ → ‘lekke’ type
● Functie
→ afsluiting vn intercell spleet tgn lumen (vb. darmlumen, galkanaal)
2.2.2 Zonula adhaerens (intermediate junction)
● Structuur
→ als gordel rond cel
→ gespecialiseerde membraanzone
- celmem vn 2 naburige cellen parallel verlopen met intercell spleet
- gevuld met fijn filamenteus materiaal (denser dn junctionele intercell ruimten)
→ aan cytoplasmatische zijde vn junctionele membraansegment
- dikke laag ineengevlochten microfilamenten (contractiel actine)
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