Pharm Exam 3 Maryville NURS 615

How do antigout medications work? - by inhibiting the infiltration and phagocytosis of leukocytes, thus decreasing the breakdown of uric acid to urate crystals. Deposition of urate crystals causes - pain and inflammation What is Colchicine - anti-gout medication how does Colchicine work? - Works by inhibiting inflammation, reducing pain and swelling common side effects of Colchicine - GI problems (diarrhea) use with caution in elderly Also can cause blood dyscrasias & abdominal pain patient education with Colchicine - Can be given with food & milk to decrease GI issues Avoid beer, ale, & wine: may cause gout attack Increase fluid intake: increases excretion of uric acid Avoid smoked meats & high-protein diets Low dose of Colchicine - Low dose colchicine is 1.2mg followed by 0.6mg one hour later or 1.8 milligrams total High dose of Colchicine - high dose colchicine is 1.2mg followed by 0.6mg every four to six hours; or 4.8mg total. Difference between high dose and low dose Colchicine - The difference between the two is low dose is as effective as high dose with a lower side effect profile. Lab values to monitor with Colchicine - Check renal function test, BUN, Creatine Patient education with Colchicine - Almost always causes some degree of diarrhea, make sure patients are aware of this side effect Patient education with Febuxostat (Uloric) - Gout may worsen with therapy initiall