Class notes
LIPOGÉNESIS LIPÓLISIS Y BETAOXIDACION
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Se describe en esquemas la lipogénesis lipólisis y betaoxidación
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APUNTES DEBIOQUIMICA
METABOLISMO DE
LIPIDOS (Acidos grasos y
trigliceridos)
, METABOLISMO DE
ACIDOS GRASOS
SINTESIS/LIPOGENESIS BREAKDOWN/BETA OXIDACION
Principal meta Formar acidos grasos Generar energia
Sitio Citoplasma Mitocondria
Hígado y tejido adiposo
Tejido musculo y otros tejidos
glandulas mamarias (Almacena
NO: cerebro que no usa lipidos, GR NO
en adipocitos)
tiene mitocondria
Precursor Acetil CoA Acyl Coa
Transportador Lanzadera de citrato Lanzadera de carnitina
Enzima que
Carnitina palmiotiltransferasa I /
determina la Acetil CoA carboxilasa
carnitina acyltransferasa I
velocidad
ATP
NAD+
Sustancias Biotina cofactor
FAD
requeridas CO2
H2O
NADPH
INSULINA
hiperglicemia
Regulacion ATP
glucagon indirectamente
positiva Estados de alta energia: ATP y
NADPH INH a la isocitrato
dehidrogenasa: +++ Citrato
glucagon hipoglicemia epinefrina Malonyl CoA (intermediario de
Regulacion
AMP y catecolaminas lipogenesis INH CAT I)
negativa
AcylCoA y palmitoil CoA Insulina (indirecto)
Acetil CoA
Productos Acido palmitico cuerpos cetonicos
finales NADP NADH+
FADH2
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