Class notes
Behaviour of Biomolecules lecture notes: Elimination Reactions
- Course
- Institution
Behaviour of Biomolecules module Lecture notes: Elimination Reactions
[Show more]
Seller
Follow
shenelshekerzade99
Content preview
BIOL1021: Behaviour of BiomoleculesDr. Ramon Rios: rrt1f11@soton.ac.uk
Behaviour of Biomolecules
Lecture 2: Elimination Reactions
, Summary Lecture 1
Nucleophilic Substitution at Saturated Carbon
2. Consider if the leaving group departs, then the nucleophile arrives.
The nucleophile
S Na
H H Leaving
Group H + Cl
Cl Departs S
H
Nucleophile H H
Arrives
The electrophile Intermediate + Na
Carbocation
This is a two-step mechanism: Step 1: The leaving group departs (SLOW)
Step 2: The nucleophile arrives (FAST)
The rate of reaction depends only on [PhCH2Cl] and the rate is NOT increased by
increasing [nucleophile] so the step involving PhCH2Cl is rate determining = Step 1.
The rate determining step is unimolecular (electrophile only) so this mechanism is
called SN1.
, Nucleophilic Substitution at Saturated Carbon
3. Consider if the arrival of the nucleophile and the departure of the leaving
group occur simultaneously.
bonds partly
The nucleophile formed/broken
S Nucleophile
H H Arrives - H H -
AND S Cl
Cl Transition state
+
Electrophile
Na Departs
The electrophile
This is a one-step mechanism: S
The rate is dependent on both the + Cl + Na
[nucleophile] and the [electrophile].
The rate determining (only) step is bimolecular (electrophile and nucleophile) so
this mechanism is called SN2. Inversion of the configuration!!!!
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller shenelshekerzade99. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $4.58. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
62890 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now