Summary
Samenvatting Wat is biochemie: inleiding
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De inleiding van het vak medische biochemie. Het gaat over de anabole en katabole reacties, metabolische flux en alle metabole wegen.
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Inleiding: wat is biochemie?= som van alle chemische reacties die in ons lichaam plaatsvinden
Anabole reactie:
- bij energetisch gunstige
situaties
- energie voor nodig
- van kleinere moleculen
naar grotere moleculen
Katabole reactie:
- bij energetisch
ongustige situaties
- grotere moleculen afbreken
- energie komt vrij
Afhankelijk vd bouwstenen opsplitsen in:
elke reactie kan anabool
of katabool zijn
Soorten metabole wegen
Alle metabole wegen staan met elkaar in communicatie!! => via ‘kruispunten’
- Glycolyse - Lipidenmetabolisme
- Mitochondriaal - Complexe lipiden
- Glucosemetabolisme - Aminozuurmetabolisme
- Hexosemonofosfaat shunt - Plasma eiwitten
- Gluconeogenese - Spiermetabolisme
- Glycogeenmetabolisme - Extracellulaire
- Vetzuurmetabolisme - Matrixproteinen
Metabolische flux
Zegt iets over hoe actief bepaalde metabole wegen zijn
=> bepaald dr veel verschillende dingen bv. extracellulaire signalen
'praten' met elkaar door
- DNA-transcriptie
- compartimentalisatie (fisiek metabole van elkaar in cel scheiden, zodat ze wel simultaan
kunnen verlopen, mr nt in contact komen)
- cofactoren (dingen die metabole wegen delen => zo kunnen ze praten, zijn altijd
koppeltjes bv NADPH & NADH)
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