Summary
BHCS2005 - Clinical Haematology and Biochemistry - Red Blood Cell Summary
- Course
- Institution
A complete summary of the red blood cell aspect of BHCS2005 clinical haematology and biochemistry module at Plymouth University.
[Show more]
Seller
Follow
hawkinsella2002
Reviews received
Content preview
Red Blood Cell Cheat SheetABO Blood Group
Discovered in 1901 by Karl Landsteiner
Routinely tested for alongside Rh
The ABO blood groups are an indirect product of the A and B alleles of the ABO gene
A and B Antigens
The antigens are oligosaccharides that are synthesised by glycosyltransferases
These glycotransferases transfer the monosaccharides to H antigen
o For A antigen, A transferase adds GalNac to H antigen
o For B antigen, B transferase adds Gal to H antigen
The ABH antigens are found at the tip of the glycan chain
Blood Group Antigens
Expressed on membrane proteins or glycoconjugates that are attached to membrane
proteins or lipids
These antigens cause blood group incompatibility
Conventional blood grouping is carried out by mixing washed RBCs with specific group
antibodies
Red Cell Membrane
The red cell membrane consists of a lipid bilayer of phospholipids
The major component of the lipid bilayer is cholesterol
The four main types of phospholipids are
o Choline
o Phosphatidylcholine
o Phosphatidylserine
o Phosphatidylethanolamine
, The membrane has a spectrin network underneath with transmembrane protein scattered
throughout
The key components of the erythrocyte membrane are
o Ankyrin-Rh complex
o Spectrin-lipid interaction
o Spectrin-ankyrin-band 3 interaction
o Spectrin dimer-dimer
Vertical and Horizontal Interactions
The vertical interactions of the cytoskeleton include
o Band 3- ankyrin
o GPC- protein 4.1R-p55 - actin
o Rh core complex-ankyrin
The horizontal interactions of the cytoskeleton include
o Spectrin dimers
o Protein 4.1R-phophatidylserine
Red Cell Membrane Components
Band 3 exchange protein is an anion exchanger which carriers the Diego blood group
o It is important for chlorine and carbonate exchange which enables rapid expulsion
o It also acts as a nucleation site for glycolytic enzymes
Protein 4.2 is needed in terms of flexibility and stability
o A reduction in band 3 also reduced protein 4.2
o This protein also binds to spectrin
Ankyrin is a major membrane anchoring protein
o It interacts with beta spectrin and band 3
o It has 3 domains
Band 3 binding domain 89kDa N-terminal
Central 62kDa regulatory binding domain
Acidic 55kDa regulatory domain C-terminal
Protein 4.1 is a protein of the skeletal network
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller hawkinsella2002. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $10.38. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
77254 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now