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FINAL EXAM REVIEW UNE MEDICAL BIOCHEMISTRY QUESTIONS AND ANSWERS
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FINAL EXAM REVIEW UNE MEDICALBIOCHEMISTRY QUESTIONS AND
ANSWERS
Under fasting conditions (ratio of insulin: glucagon <1), elevated glucagon will activate which of
the following enzymes? - answer hormone sensitive lipase
Ketonuria, hypoglycemia, and severe acidosis are prime diagnostic indicators of the
presentation of type 1 diabetic ketoacidosis. Which of the following compounds are "ketone
bodies" that would be elevated in serum of urine of a patient in this condition? - answer D-3-
hydroxybutyrate and acetoacetate
What is the purpose of cholesterol esterification within the cell? (the conversion of cholesterol
to cholesteryl ester)
a. this modification makes cholesterol more soluble in the plasma membrane
b. this modification does not change the chemical properties of cholesterol
c. esterification is the first step in the synthesis of cortisol
d. esterification traps cholesterol in the cell - answer esterification traps cholesterol in the cell
An individual goes to bed around 8 pm and doesn't wake up until 9 am the next morning.
During this time, which of the following is the primary oxidizable substrate in the skeletal
muscle?
a. free fatty acids
b. glycogen
c. amino acids
d. lactate - answer free fatty acids
A 22-year-old woman engaging in a political protest goes on a hunger strike on a prominent
corner in a city park. She refuses all offers of food for except for water through the first 2 weeks.
, Under these conditions there is a decreased reliance on which of the following pathways for
fuel?
a. β-oxidation
b. ketogenesis
c. gluconeogenesis
d. lipolysis - answer gluconeogenesis
In reverse cholesterol transport HDL interacts with the ABCA1 transporter to move cholesterol
from the cell to the HDL. This also requires the activity of which of the following enzyme?
a. lipoprotein lipase
b. cholesteryl ester transfer protein (CETP)
c. lecithin cholesterol acyltransferase (LCAT)
d. LDL receptor - answer lecithin cholesterol acyltransferase (LCAT)
A 16-year-old woman presents to her primary care physician for a follow up visit. At her initial
visit, 3 months ago, her serum cholesterol was 255 mg/dL (above normal). She finds this very
disappointing as she started a strict dietary regime reducing all fats and cholesterol, replacing
them with a high carbohydrate diet. You tell her that high carbohydrate diets can increase
serum triglyceride levels in some individuals. This can be attributed in an increase in the
synthesis of which of the fol - answer VLDL
a 5-year-old presents to her primary care physician. Her mother is concerned due to persistent
diarrhea which is worse when eating fatty foods. The child also has some clinical signs of a
deficiency in fat-soluble vitamins. Based on this information the child likely has a deficiency in
the ability to synthesize which of the following lipoproteins?
a. chylomicrons
b. VLDLs
c. LDLs
d. HDLs - answer chylomicrons
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