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UNE BIOCHEMISTRY MIDTERM STUDY GUIDE QUESTIONS FULLY SOLVED & UPDATED 2023.
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UNE BIOCHEMISTRY MIDTERM STUDY GUIDE QUESTIONS FULLY SOLVED & UPDATED 2023.
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UNE BIOCHEMISTRY MIDTERM STUDYGUIDE QUESTIONS FULLY SOLVED &
UPDATED 2023
A 19-year-old boy is diagnosed with Creutzfeldt-Jakob disease which is caused by the
introduction of an amyloid fold in the disease-causing protein. The introduction of this fold
causes the protein to transition from a primarily alpha helical structure to an aggregate of
mostly beta sheets. This change in protein structure (leading to disease) is best attributed to
changes in which of the following? - answer folding of the secondary structures
Which of the following is the best description of primary protein structure? - answer a newly
synthesized strand of amino acids
How do most enzymes reduce the activation energy needed to move a reaction forward? -
answer providing an active site most complementary the transition state
Movement of ammonia from an amino acid to an a-keto acid involves a family of enzymes best
categorized as which of the following? - answer transferases
Hemoglobin has the ability to display cooperative binding while myoglobin does not display this
binding kinetic pattern. Which of the following differences between the two proteins accounts
for this difference in binding kinetics? - answer the presence of quaternary structure
Changes in the physiological variables listed below can alter the affinity of hemoglobin for
oxygen. Which of the following will lower the affinity of hemoglobin for oxygen? - answer
increase in 2,3 bisphosphoglycerate (BPG)
An enzyme has a mutation within the substrate binding site that reduces the binding of the
coenzyme needed for covalent catalysis. Which of the following is likely to result as a
consequence of this mutation? - answer the enzyme will not be able to form the transition state
complex
, Chymotrypsin is a protease that cleaves peptide bonds. It is characterized as which of the
following classes of enzymes? - answer hydrolases
If a mutation is made within the active site of an enzyme resulting in a decrease in Km, which of
the following will be true with respect to the enzyme kinetics? - answer the enzyme will require
a lower substrate concentration to reach 1/2 Vmax
Which of the following best describes an enzyme inhibitor that increases the Km but does not
change the Vmax? - answer a competitive inhibitor
An enzyme is participating in a general acid-base catalysis reaction with an optimal reaction pH
of 6.0. If acid is added to the environment reducing the pH to 3, what is the Iikely impact to the
rate of the reaction? - answer the rate of the reaction is likely to decrease as the pH is out of
optimal catalytic range
A new enzyme is discovered that increases in activity when it is phosphorylated on an exposed
tyrosine residue. Phosphorylation of this amino acid is classified as which of the following? -
answer covalent modification
In the image below the blue line indicates enzyme kinetics with no inhibitor present. Based on
this information, which of the following is true? - answer the green line shows enzyme kinetics
with the addition of a noncompetitive inhibitor
An example of enzyme activation by cleavage is best illustrated by which of the following? -
answer activation of chymotrypsinogen to chymotrypsin
Use the figure below to compare the activities of glucokinase and hexokinase. Based on this
information, which of the following is a true statement? - answer glucokinase has a higher Km
than hexokinase
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