UNE MEDICAL BIOCHEM FINAL EXAM
QUESTIONS AND ANSWERS
The cellular uptake of LDL increase intracellular cholesterol levels. This has which of the
following impacts on de novo cholesterol synthesis? - answer Increases degradation of HMG-
CoA reductase
Dietary cholesterol is primarily transported in the body by which of the following lipoproteins? -
answer Chylomicrons.
Cholesterol and TG from diet are transported from intestine to liver via chylomicrons.
The LDL receptor is also highly regulated in the cell. Which of the following proteins targets the
LDL receptor for degradation? - answer Proprotein converts subtillisin/kexin type 9 (PSK9)
Bile salts are synthesized from cholesterol and are used for the emulsification of dietary lipids.
What is the primary fate of bile salts during digestion? - answer They are absorbed in the ileum.
Secondary bile salts are excreted in the feces.
A deficiency in the LDL receptor will result in an initial decrease in which of the following? -
answer Intracellular cholesterol
A 45-year-old man has a mild heart attack and a history of vascular disease. He is placed on a
Mediterranean diet and statin drug therapy. Which of the following will be the most likely result
of this drug therapy? - answer Low blood LDLs
Statins: directly reduce de novo cholesterol synthesis and increase LDL receptor expression--
>increase LDL uptake and reduce circulating levels of LDLs
, Secondary bile salts lack a hydroxyl (OH) group when compared to primary bile salts. What is
the consequence of the loss of this group? - answer Secondary bile salts are less soluble.
Less likely to be absorbed.
Which of the following is NOT required for the transport of newly synthesized fatty acids to the
adipose? - answer Carnitine to shuttle the fatty acids out of the mitochondria.
Carnitine shuttle is required for the process of beta-oxidation to transport fatty acyl chains into
the mito.
What is the primary component of a VLDL particle? - answer Triagcylglycerols
From de novo synthesis in the liver.
A 5-year-old presents to her primary care physician. Her mother is concerned due to persistent
diarrhea which is worse when eating fatty foods. The child also has some clinical signs of a
deficiency in vitamins A, D, E, and K (fat soluble vitamins). Based on this information, the child
likely has a deficiency in the ability to synthesize which of the following lipoproteins? - answer
Chylomicrons
Chylomicrons transport dietary fats and fat soluble vitamins.
VLDL particles have which of the following combinations of apoproteins in their mature form? -
answer ApoB100, ApoCII, ApoE
Which of the following is the major source of extracellular cholesterol for human tissues? -
answer LDLs
Primary role of LDL: transport cholesterol to peripheral tissues
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller FREEMANSHARP. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $14.99. You're not tied to anything after your purchase.