Exam (elaborations)
BMTCN NUMBERS TO KNOW
- Course
- Institution
BMTCN NUMBERS TO KNOW
[Show more]
Seller
Follow
FREEMANSHARP
Reviews received
Content preview
FOUNDATIONS OF TRANSPLANT EXAMQUESTIONS AND ANSWERS
CXCR4 - answer Regulates trafficking and homing of stem cells
Expressed on surface of HSCs
1st stem cell transplant - answer 1960's, infant with immunodeficiency disorder, matched sib
SDF-1 - answer Secreted by bone marrow stromal cells
Involved in retaining HSCs within bone marrow as well as releasing HSCs into circulation
Stem cell retention in bone marrow - answer Involves SDF-1 gradient, cellular adhesion
molecules (CAMs), and binding action of CXCR4
Myeloid progenitor cells differentiate into... - answer - RBCs
- Megakaryocyte (platelets)
- Neutrophils
- Basophils
- Eosinophils
- Monocytes/macrophages
- Dendritic cells
- Mast cells
Goals of transplant: non-malignant diseases - answer Cell line replacement
, Goals of transplant: malignant diseases - answer Tumor ablation
Graft vs. Tumor effect - answer - Promoted by withdrawal of immunosuppression
- Promoted by DLI
- Decreases in absence of GVHD
Common hematological malignancies treated with auto HSCT - answer - Hodgkin disease
- Non-Hodgkin lymphoma
- Multiple myeloma
Common hematological malignancies treated with allo HSCT - answer - ALL
- AML
- CML
- MDS
- NHL
- Juvenile myelomonocytic leukemia
Solid tumors treated with auto HSCT - answer - Neuroblastoma
- Sarcoma
- Germ cell tumors
- Brain tumors
- Ovarian cancer
- Melanoma
- Lung cancer
Common non-malignant hematologic diseases treated with allo HSCT - answer - Severe aplastic
anemia
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller FREEMANSHARP. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $13.49. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
79650 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now