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BMTCN EXAM PRACTICE QUESTIONS AND ANSWERS 2023
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BMTCN EXAM PRACTICE QUESTIONS AND ANSWERS 2023
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BMTCN REVIEW QUESTIONS WITH100% CORRECT ANSWERS 2023
Why are cell renewal mechanisms important? - answer Because of senescene, utilization, and
emigration
What is the objective of hematopoiesis? - answer Maintain peripheral blood with a constant
level of different types of blood cells
What is immune function partially dependent on? - answer Hematopoiesis
Define innate immunity: - answer These responses occur naturallyand utilize phagocytic cells
that release inflammatory mediators as well as nature killer (NK) cells.
Define acquired immunity: - answer The responses involve antigen specific B and T cells and are
either humoral or cell mediated.
When do problems arise in the immune system? - answer Problems arise when there is
overwhelming infection, inherited genetic mutations, acquired disorders, aging, and
medications that interfere with normal immune function
Red Bone Marrow - answer Consists of HSCs and originates in flat and long bones. At birth, BM
is red and converts to yellow as one ages.
Yellow Bone Marrow - answer Consists of fat cells and resides in the hollow interior of the
middle portion of long bones. At birth, BM is red and converts to yellow as one ages.
BM during fetal development: - answer Hematopoiesis occurs in the liver and yolk sac. 20th
week of gestation, BM begins to produce blood cells, and by week 30, BM has achieve normal
cellularity. 90% at birth.
, BM during childhood: - answer Hematopoiesis occurs in the long bones.
BM at age 30: - answer Hematopoiesis occurs exclusively in the axial skeleton, pelvis, vertebrae,
ribs, sternum, and skull. Cellularity is at 50%
BM at age 70: - answer Declines to 30% cellularity
Define extramedullary hematopoiesis: - answer If BM injury occurs, hematopoiesis can resume
in the liver and spleen
What plays a critical role in the immune system by developing and training T cells for adaptive
immune function? - answer Thymus
When is the thymus most active? - answer From birth through puberty
What happens to the thymus during puberty? - answer Anatomically reduces in size and is
replaced with fatty tissue; this results in a decline in hematopoietic tissue as well as adaptive
immunity
In healthy individuals, what is the circulation of HSCs? - answer Peripherally 0.06% and BM is
1.1%
Why do HSCs spend a majority of their time outside of the cell cycle? - answer Quiescent; they
are activated for the purpose of homeostasis or tissue repair
How often do HSCs regenerate? - answer Every two to three months
Why can progenitor cells not renew? - answer They always commit to one specific cell
differentiation pathways that lead to the production of specific blood cells
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