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Samenvatting Top 150 geneesmiddelen humaan gebruik 21-22 - Officinastages en casuïstiek (4023701ENR)
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Samenvatting van de top 150 geneesmiddelen in België. Voorzien van alle gegevens die vermeld staan in het kenniscompetentiedocument.

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  • November 26, 2023
  • 288
  • 2021/2022
  • Summary

Subjects

  • stage examen
  • top 150 gm
  • top 150 geneesmiddelen humaan gebruik
  • officinastages en casuïstiek

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  • Vrije Universiteit Brussel (VUB)
  • Farmaceutische Wetenschappen
  • (4023701ENR)

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Top 150 geneesmiddelen
1. TRACT AND METABOLISM .................................................................................................................... 5
ZOUTCOMBINATIES AL, CA EN MG — A02AD01 ........................................................................................ 5
MAGALDRAAT — A02AD02 ........................................................................................................................... 6
OMEPRAZOLE — A02BC01 ........................................................................................................................... 7
PANTOPRAZOLE — A02BC02 ........................................................................................................................ 8
ESOMEPRAZOLE — A02BC05 ....................................................................................................................... 9
ALGINEZUUR — A02BX13 .......................................................................................................................... 10
OTILIUM BROMIDE — A03AB06 ................................................................................................................. 11
BUTYLSCOPOLAMINE (BUTYLHYOSCINE) — A03BB01 .............................................................................. 12
METOCLOPRAMIDE — A03FA01 ................................................................................................................. 13
DOMPERIDON — A03FA03 ......................................................................................................................... 14
ALIZAPRIDE — A03FA01 ............................................................................................................................ 15
BISACODYL — A06AB02 ............................................................................................................................. 16
LACTULOSE — A06AB11 ............................................................................................................................. 17
MACROGOL EN COMBINATIEPREPARATEN — A06AD65 ............................................................................ 18
LOPERAMIDE — A07DA03 .......................................................................................................................... 19
NATRIUMFOSFAAT — A06AG01 ................................................................................................................. 20
GLYCEROL — A06AX01............................................................................................................................... 22
INSULINE ASPART — A10AB05 .................................................................................................................. 23
INSULINE GLARGINE — A10AE04 .............................................................................................................. 24
METFORMINE — A10BA02 .......................................................................................................................... 25
GLICAZIDE — A10BB09 ............................................................................................................................. 26
2. BLOOD AND BLOOD FORMING ORGANS ............................................................................................. 27
ACENOCOUMAROL — B01AA07 .................................................................................................................. 27
WARFARINE — B01AA03 ............................................................................................................................ 28
ENOXAPARINE — B01AB05 ........................................................................................................................ 29
NADROPARINE — B01AB06 ........................................................................................................................ 31
CLOPIDOGREL — B01AC04 ........................................................................................................................ 33
ACETYLSALICYLZUUR — B01AC06 ............................................................................................................. 35
RIVAROXABAN — B01AF01 ........................................................................................................................ 37
APIXABAN — B01AF02 ............................................................................................................................... 39
3. CARDIOVASCULAR SYSTEM ................................................................................................................ 40
FLECAÏNIDE — C01BC04 ............................................................................................................................ 40
AMIODARON — C01BD01 ........................................................................................................................... 42
MOLSIDOMINE — C01DX12 ....................................................................................................................... 43
MOXONIDINE — C02AC05.......................................................................................................................... 45
INDAPAMIDE — C03BA11 ........................................................................................................................... 46
FUROSEMIDE — C03CA01 .......................................................................................................................... 48
BUMETANIDE — C03CA02 .......................................................................................................................... 50
SPIRONOLACTON — C03DA01 ................................................................................................................... 52
PROPRANOLOL — C07AA05 ........................................................................................................................ 54
SOTALOL — C07AA07................................................................................................................................. 56
METOPROLOL — C07AB02 ......................................................................................................................... 58
BISOPROLOL — C07AB07........................................................................................................................... 60
NEBIVOLOL — C07AB12 ............................................................................................................................. 62
BISOPROLOL MET THIAZIDEN — C07BB07................................................................................................ 65
AMLODIPINE — C08CA01 ........................................................................................................................... 66
LERCANIDIPINE — C08CA13 ...................................................................................................................... 67



1

, DILTIAZEM — C08DB01 ............................................................................................................................. 68
DIKALIUMCLORAZEPAAT— N05BA05 ......................................................................................................... 70
LISINOPRIL — C09AA03 ............................................................................................................................. 72
PERINDOPRIL — C09AA04 ......................................................................................................................... 74
RAMIPRIL — C09AA05 ................................................................................................................................ 76
PERINDOPRIL MET DIURETICA — C08BA04............................................................................................... 78
PERINDOPRIL MET AMLODIPINE — C09BB04 ............................................................................................ 79
LOSARTAN — C09CA01 .............................................................................................................................. 82
OLMESARTAN — C09CA08 ......................................................................................................................... 83
SIMVASTATINE — C10AA01 ....................................................................................................................... 84
PRAVASTATINE — C10AA03 ....................................................................................................................... 86
ATORVASTATINE ............................................................................................................................................. 88
EZETIMIBE — C10AX09 .............................................................................................................................. 90
ROSUVASTATINE — C10AA07 .................................................................................................................... 91
FENOFIBRAAT — C10AB05 ......................................................................................................................... 93
4. DERMATOLOGICS ............................................................................................................................... 94
MICONAZOL — D01AC02 ........................................................................................................................... 94
IMIDAZOL/TRIAZOLDERIVATEN MET CORTICOSTEROÏDEN — D01AC20 (LORTIDERM) ......................... 95
IMIDAZOL/TRIAZOLDERIVATEN MET CORTICOSTEROÏDEN — D01AC20 (TRAVOCORT)......................... 97
IMIDAZOL/TRIAZOLDERIVATEN MET CORTICOSTEROÏDEN — D01AC20 (DAKTACORT) ........................ 99
ZINKPRODUCTEN — D02AB (DAKTOZIN) ................................................................................................ 100
ZINKPRODUCTEN — D02AB (LIPACTIN) .................................................................................................. 101
ZINKPRODUCTEN — D02AB (ZINERYT) ................................................................................................... 102
ZINKPRODUCTEM — D02AB (INOTYOL) .................................................................................................. 103
ZINKPRODUCTEN — D02AB (ALOPATE) .................................................................................................. 104
ZINKPRODUCTEN — D02AB (ZINXYDERM).............................................................................................. 105
FUSIDINEZUUR — D06AX01 .................................................................................................................... 106
ACICLOVIR — D06BB03 ........................................................................................................................... 107
HYDROCORTISON — D07AA02 ................................................................................................................ 108
BETAMETASON — D07AC01 ..................................................................................................................... 110
MOMETASON — D07AC13 ........................................................................................................................ 112
CLOBETASOL — D07AD01........................................................................................................................ 113
5. GENITO-URINARY SYSTEM AND SEX HORMONES...............................................................................115
DESOGESTREL MET ETHINYLESTRADIOL — G03AA09 ............................................................................ 115
LEVOGESTREL MET ETHINYLESTRADIOL — G03AA07 ............................................................................. 118
DESOGESTREL — G03AC09 ..................................................................................................................... 121
ESTRADIOL — G03CA03........................................................................................................................... 123
PROGESTERON — G03DA04..................................................................................................................... 125
SILDENAFIL — G04BE03 .......................................................................................................................... 127
TAMSULOSINE — G04CA02 ...................................................................................................................... 129
6. SYSTEMIC HORMONAL PREPARATIONS (EXCL. SEX HORMONES AND INSULINS) ................................130
METHYLPREDNISOLON — H02AB04 ......................................................................................................... 130
LEVOTHYROXINE — H03AA01 .................................................................................................................. 133
7. ANTI-INFECTIVES FOR SYSTEMIC USE .................................................................................................135
AMOXICILLINE — J01CA04 ....................................................................................................................... 135
FLUCLOXACILLINE — J01CF05 ................................................................................................................. 137
AMOXICILLINE MET ENZYMREMMER — J01CR02 ..................................................................................... 139
CLARITHROMYCINE — J01FA09................................................................................................................ 140
AZITHROMYCINE — J01FA10.................................................................................................................... 142
CLINDAMYCINE — J01FF01 ...................................................................................................................... 144
CIPROFLOXACINE — J01MA02 ................................................................................................................. 146


2

, NITROFURANTOÏNE — J01XE01 ............................................................................................................... 148
FOSFOMYCINE — J01XX01 ....................................................................................................................... 150
FLUCONAZOL — J02AC01 ......................................................................................................................... 151
ACICLOVIR — J05AB01 ............................................................................................................................ 153
INFLUENZAVACCIN, GEZUIVERD ANTIGEEN — J07BB02 ........................................................................ 155
8. L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ................................................................157
METHOTREXAAT — L04AX03 .................................................................................................................... 157
9. MUSCULO-SKELETAL SYSTEM ............................................................................................................159
DICLOFENAC — M01AB05 ........................................................................................................................ 159
PIROXICAM — M01AC01 .......................................................................................................................... 161
MELOXICAM — M01AC06 ......................................................................................................................... 163
IBUPROFEN — M01AE01........................................................................................................................... 164
NAPROXEN — M01AE02 ........................................................................................................................... 166
ETOFENAMINEZUUR — M02AA06............................................................................................................. 168
DICLOFENAC — M02AA15 ........................................................................................................................ 169
PREPARATEN MET SALICYLZUURDERIVATEN (REPARIL®) — M02AC .................................................... 170
PREPARATEN MET SALICYLZUURDERIVATEN (DIPROSALIC®) — M02AC .............................................. 171
PREPARATEN MET SALICYLZUURDERIVATEN (APORIL®, DUOFILM®) — M02AC ................................ 172
BACLOFEN — M03BX01 ............................................................................................................................ 173
ALLOPURINOL — M04AA01 ...................................................................................................................... 175
10. NERVOUS SYSTEM ........................................................................................................................177
OXYCODON — N02AA05 .......................................................................................................................... 177
DIHYDROCODEINE — N02AA08 ............................................................................................................... 178
FENTANYL — N02AB03 ............................................................................................................................. 179
CODEINE MET PARACETAMOL — M02AJ06 .............................................................................................. 180
TRAMADOL MET PARACETAMOL — N02AJ13 ............................................................................................ 182
TILIDINE — N02AX01 ............................................................................................................................... 184
TRAMADOL — N02AX02 ........................................................................................................................... 186
ACETYLSALICYLZUUR — N02BA01 ........................................................................................................... 188
PARACETAMOL — N02BE01 ...................................................................................................................... 190
PARACETAMOL + COFFEÏNE + ASA + ASCORBINEZUUR + CHLOORFENAMINE, COMBINATIEPREPARAAT
EXCLUSIEF PSYCHOLEPTICA — N02BE51................................................................................................. 192
CLONAZEPAM — N03AE01 ....................................................................................................................... 195
CARBAMAZEPINE — N03AF01 .................................................................................................................. 197
VALPROÏNEZUUR — N03AG01 ................................................................................................................. 199
LAMOTRIGINE — N03AX09....................................................................................................................... 201
LEVETIRACETAM — N03AX14 ................................................................................................................... 203
PREGABALINE – N03AX16 ........................................................................................................................ 205
LEVODOPA MET DECARBOXYLASEREMMER — N04BA02 ......................................................................... 206
QUETIAPINE — N05AH04 ......................................................................................................................... 208
DIAZEPAM — N05BA01 ............................................................................................................................ 210
LORAZEPAM — N05BA06 .......................................................................................................................... 212
BROMAZEPAM — N05BA08....................................................................................................................... 213
PRAZEPAM — N05BA11 ............................................................................................................................ 214
ALPRAZOLAM — N05BA12 ........................................................................................................................ 216
LORMETAZEPAM — N05CD06 ................................................................................................................... 218
ZOPICLON — N05CF01 ............................................................................................................................. 219
ZOLPIDEM — N05CF02 ............................................................................................................................. 220
AMITRIPTYLINE — N06AA09 .................................................................................................................... 221
PAROXETINE — N06AB05......................................................................................................................... 223
SERTRALINE — N06AB06 ......................................................................................................................... 225
ESCITALOPRAM — N06AB10 .................................................................................................................... 227


3

, TRAZODON — N06AX05 ........................................................................................................................... 229
MIRTAZEPINE — N06AX11 ....................................................................................................................... 231
VENLAFAXINE — N06AX16 ....................................................................................................................... 232
DULOXETINE — N06AX21 ........................................................................................................................ 234
METHYLFENIDAAT — N06BA04 ................................................................................................................ 235
MELITRACEEN MET PSYCHOLEPTICA — N06CA02 ................................................................................... 238
NICOTINE — N07BA01 ............................................................................................................................. 240
BETAHISTINE — N07CA01 ....................................................................................................................... 243
11. RESPIRATORY SYSTEM ..................................................................................................................244
OXYMETAZOLINE — R01AA05 .................................................................................................................. 244
XYLOMETAZOLINE — R01AA07 ................................................................................................................ 246
TRAMAZOLINE — R01AA09 ...................................................................................................................... 248
MOMETASON — R01AD09 ........................................................................................................................ 249
FLUTICASONFUROAAT — R01AD12 ......................................................................................................... 250
PSEUDOEFEDRINE, COMBINATIEPREPARATEN — R01BA52 .................................................................... 251
FENYLEFRINE, COMBINATIEPREPARATEN — R01BA53 ............................................................................ 253
DICHLOORBENZYLALCOHOL — R02AA03 ................................................................................................ 255
FLURBIPROFEN — R02AX01 ..................................................................................................................... 257
SALBUTAMOL — R03AC02 ........................................................................................................................ 258
SALMETEROL MET FLUTICASON — R03AK06 ........................................................................................... 260
FORMOTEROL MET BUDESONIDE — R03AK07 ......................................................................................... 262
FORMOTEROL MET BECLOMETASON — R03AK08 .................................................................................... 264
VILANTEROL MET FLUTICASONFUROAAT — R03AK10............................................................................. 266
FENOTEROL MET IPRATROPIUMBROMIDE — R03AL01 ............................................................................ 267
BUDESONIDE — R03BA02........................................................................................................................ 269
IPRATROPIUMBROMIDE — R03BB01 ........................................................................................................ 271
MONTELUKAST — R03DC03 ..................................................................................................................... 273
ACETYLCYSTEÏNE — R05CB01 ................................................................................................................. 274
BROOMHEXINE — R05CB02 ..................................................................................................................... 276
CARBOCISTEÏNE — R05CB03 ................................................................................................................... 277
CODEINE — R05DA04 .............................................................................................................................. 278
DEXTROMETORFAN — R05DA09 .............................................................................................................. 279
CETIRIZINE — R06AE07 ........................................................................................................................... 281
LEVOCETIRIZINE — R06AE09 .................................................................................................................. 282
DESLORATADINE — R06AX27 .................................................................................................................. 283
BILASTINE — R06AX29 ............................................................................................................................ 284
12. SENSORY ORGANS ........................................................................................................................285
TIMOLOL, COMBINATIEPREPARATEN — S01ED51 ................................................................................... 285
LATANOPROST — S01EE01 ...................................................................................................................... 287




4

, 1. tract and metabolism


Actieve stof Zoutcombinaties Al, Ca en Mg — A02AD01

• Neutraliseren het maagzuur waardoor pH in de maag
stijgt. Pepsinogeen kan niet worden omgezet tot pepsine.
Farmacologie
Snelle korte werking.
• Lichte absorptie, eliminatie via faeces
• Algeldraat, Mg-oxide/hydroxide,
Mernknamen/ toe- magaldraat, carbonaatverbindingen
dieningsvormen • Gaviscon, Maalox Antacid, Rennie
• Zuigtablet, kauwtablet, zakjes, suspensie, siroop
(special) Gebruik Niet langdurig, suspensie schudden

Indicatie met • Dyspepsie/gastritis, pyrosis, reflux
dosering
• 2-4 koffielepels, 4 tabletten 4x/dag
Terugbetalings-
O
modaliteit

Innamemoment 2u tijd tussen met andere GM, 4u met chinolonen, na eten

Contra-
indicaties Hypofosfatemie, ernstige NI, overgevoeligheid

• Gewijzigde resorptie van GM door pH-wijziging maag,
vorming niet-resorbeerbare complexen (tetracyclines,
Interacties chinolones, ijzer)
GM/ voeding • NaHCO3: urinaire excretie GM verandert, meer kans
nierstenen door alkalinisatie urine
• Al: encephalopathie als NI bij associatie met
citraten/ascorbinezuur
• Mg: diarree, Mg-retentie bij NI
Bijwerkingen • NaHCO3: maaguitzetting, flatulentie door
vorming CO2, zoutretentie
• Al: obstipatie
Zwangerschap/
Geen hoge dosissen, niet langdurig
borstvoeding

Nier- en of lever-
Reductie of CI bij ernstige nierinsufficiëntie met Al en Mg-zouten
insufficiëntie




5

, Actieve stof Magaldraat — A02AD02

• Complex reageert met maagzuur, hydroxymagnesium
wordt magnesiumionen (laxerend), aluminaat tot Al-
hydroxide. Dit reageert met HCl van maag tot vorming
AlCl3 (constiperend), neutralisatie maagzuur,
beschermende laag op maagwand, bindt aan pepsine en
Farmacologie galbestanddelen (agressieve werking van het maagsap
opgehoffen)
• Lage tot geen absorptie (stijgt bij hogere dosis),
eliminatie via faeces (oplosbare fosfonaten),
uitzonderlijk verhoogde
Al-serumspiegels gevonden (zelfs bij gewone nierfunctie)
Mernknamen/ toe- • Riopan (800mg/10mL), Gastricalm (400mg)
dieningsvormen
• Kauwtablet, suspensie (zakjes)
Niet langdurig, zakjes kneden en uit zakje drinken, suspensie
(special) Gebruik
schudden
• Reflux, gastritis: 800mg (2 tabletten of 10 mL)
Indicatie met • Korte behandeling maag- of darmulcus, klachten door
dosering GM: 5-6 tabletten, ≠ keren 800mg riopan
Maximale dagdosis: 6400 mg
Terugbetalings-
O
modaliteit
1u na maaltijd en voor slapen (igv duodenumzweer ook 3u na
Innamemoment
maaltijd)
Contra-
ernstige NI, overgevoeligheid
indicaties

• Gewijzigde resorptie van GM door pH-wijziging maag,
vorming niet-resorbeerbare complexen (tetracyclines,
Interacties
chinolones, ijzer)
GM/ voeding
• Al: encephalopathie als NI bij associatie met
citraten/ascorbinezuur, alcohol, koffie
• Mg: diarree, Mg-retentie bij NI
Bijwerkingen
• Al: obstipatie
Zwangerschap/
Geen hoge dosissen, niet langdurig
borstvoeding

Nier- en of lever- Reductie bij sterk verminderde nierfunctie of CI bij ernstige
insufficiëntie nierinsufficiëntie met Al en Mg-zouten




6

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