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Class notes 4BBY1013 (Biochemistry)

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complete class notes for lecture: Lipids and membranes taken in academic year 2022/2023

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  • November 28, 2023
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  • 2022/2023
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Lecture 04 – Lipids and molecules


Learning outcomes
 describe the major lipid components of cell membranes, (glycerophospholipids, sphingolipids and cholesterol) and be able
to explain features of these molecules that confer hydrophobic and hydrophilic qualities.
 recognize and correctly name examples of the above classes of lipids and examples of fatty acids commonly found in
biological molecules.
 understand the effects that unsaturation of the fatty acid components of glycerophospholipids confer on the physical
properties of these molecules.
 describe membrane fluidity in molecular terms and identify characteristics of the components of membranes that influence
this factor.
 Give a brief account of the permeability characteristics of the lipid bilayer to different classes of molecule.




Lipids and fats

Lipids: molecules in cells that are water-insoluble (hydrophobic) but soluble in organic solvents e.g.
 Triacylglycerols (fats and oils)
 Glycerophospholipids and other membrane lipids
 Steroids and cholesterol

Dietary and storage lipids are triacylglycerols (neutral fats).
 Hydrophobic molecules
 Form droplets in water or aqueous environment.
 Important energy storage molecules




Membrane lipids

,  Polar amphipathic molecules.
 The most common class of polar membrane lipid are phospholipids, mostly based on glycerol –
glycerophospholipids
 Basic structure of glycerophospholipids compared to triacylglycerols
 Instead of a third fatty acid we have a phosphate attached to a polar head group (labelled ‘amino alcohol’
here)




Polar head groups found in phospholipids

 Amino alcohols

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