Summary
Histologie samenvatting Celadhesie
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Dit is een samenvatting van het hoofdstuk 'Celadhesie' van het vak histologie. Dit wordt gedoceerd in de 1e bachelor Biomedische Wetenschappen en Geneeskunde.
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HT 3: CeladhesieCeladhesie
= Cel hangt zich vast aan andere cellen
Interactie plasmamembraan met:
o Andere cel:
Cadherinen
Selectinen
Immuglobulinen
Enkele integrinen
o Extracellulaire matrix:
Integrinen
Wederzijdse interactie cel-omgeving
Belangrijk in vele processen, o.a. metastasering (=doordringen in ander weefsel), afsluiten
bepaalde openingen bv. slokdarm
ECM
Samenstelling
1. Grondsubstantie
2. Vezels
o Collagene vezels
stevige vezels bv. pezen
o Elastische vezels
Rekbaarheid aan ECM
3. Weefselvloeistof:
o Samenstelling van bloedplasma
o Tekort = dehydratatie, te veel = oedeem
cellen kunnen niet uitdrogen
Afbraak door MMPs (= matrix metalo proteases)
, Integrinen
Plaatsen van voorkomen:
Transmembranair (doorheen celmembraan)
Extracellulair: binden matrix
Intracellulair: bindt op actinefilamenten of intermediaire filamenten via koppelproteïnen (op
cytoskelet)
Basale membraan
=fijne extracellulaire lamel
Plaatsen van voorkomen:
Op overgang tss 2 weefsels
- Tss epitheel en bindweefsel
- Rond spierweefsel
- Rond steuncellen v/d perifere zenuwvezels
- Rond vetcellen
Opbouw:
- Parenchym- en bindweefselcellen (rijk aan suikers)
3 lagen:
1. Lamina lucida lucida: helder
Glycoproteïnen fibronectine en laminine
2. Lamina densa basale lamina
50 nm elektrondense laag
Glycoproteïnenmatrix met collageen type IV
3. Lamina diffusa of lamina (fibro)reticularis
Collagene fibrillin (o.a. type I, III, VII)
! elke laag bevat ook glycosaminoglycanen en proteoglycanen
Functies:
- Steun en hechting
- Scheidingsfunctie: doordringbaar voor nutriënten, lymfocyten & granulocyten
- Regulering van celdeling en differentiatie
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