Local Anesthetics are the drugs which upon topical application and local injection cause reversal loss of sensory.
They are the only drugs used clinically to block the voltage gated sensitive sodium channels and inhibit generation of action potential.
LAs are either esters or amides.
Esters are ...
The LA block nerve conduction by decreasing the entry of
Sodium Ions during upstroke of action potential.
When concentration of LA will increase , rate of action
potential will also increase which will cause Depolarization
and will result in slow conduction.
Local depolarization fails to reach the threshold potential
and conduction blocks.
At physiological pH,
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