Chapter18: ARTHRITIS AND COMMON TISSUE
DISEASES STUDY GUIDE
LUPUS ERYTHEMATOSUS (DLE/SLE)
>>> PATHO
• Lupus is probably caused by a complex combo of genetic and environmental factors
• 2 main classifications:
o Discoid lupus erythematosus (DLE) – effects only the skin
o Systemic lupus erythematosus (SLE) – more common
• Systemic lupus erythematosus (SLE):
o Chronic, progressive, inflammatory connective tissue disorder that can
cause major body organs/systems to fail
o Spontaneous remissions and exacerbations
o Onset may be acute or insidious (slow)
o Potentially fatal, but most live many years
o Autoimmune process – invades organs or deprives them of blood and oxygen
o Immune complexes invade organs directly or cause vasculitis (vessel
inflammation), which deprives the organs of arterial blood and
oxygen.
o Autoimmune complexes tend to be attracted to glomeruli of the kidneys
o Often some degree of kidney involvement (lupus nephritis) – this is the
leading cause of death from this disease
o Onset at 20-40 years old
>>> ASSESSMENT
>> PHYSICAL ASSESSMENT
• When in remission pt. may
appear fully healthy
• When disease flares up, pt. may
need to be admitted to the
hospital
1
,• MT skin condition daily and at
every home visit
OTHER Fever (indicates exacerbation) Fever
Fatigue Fatigue
3
, Anorexia Anorexia
Weight loss Vasculitis
Generalized weakness
Vasculitis
Osteonecrosis (bone necrosis from lack
of oxygen)
- most common in the hip
>> PSYCHOSOCIAL ASSESSMENT
4
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