What is the ECM?
ANS
Extracellular matrix
a network of proteins and polysaccharide chains that are secreted by cells
What are the two forms of the ECM? What are they each?
ANS
ECM of connective tissue= fibrous polymers like collagen
Basal Lamina= flexible, thin mat of specialized ECM that un...
What is the ECM?
ANS
Extracellular matrix
a network of proteins and polysaccharide chains that are secreted by cells
What are the two forms of the ECM? What are they each?
ANS
ECM of connective tissue= fibrous polymers like collagen
Basal Lamina= flexible, thin mat of specialized ECM that underlies epithelial cell sheets
and tubes
What are the two ways that cells are attached in tissue?
ANS
either to the basal lamina or to the ECM and to each other
What are the 4 main types of junctions?
ANS
1. Tight junction
2. Cell-cell anchoring junction (adherens and desmosomes)
3. Gap junction
4. Cell-matrix anchoring junction (hemidesmosome and actin-linked cell-matrix junction)
What are cadherins? What are they made of? What do they depend on?
ANS
,-anchoring junction that links cells together
-transmembrane protein
-depend on Ca
cadherens = ca2+ + adherins
What are integrins?
ANS
anchoring junction that links cells to the ECM
What are adherins junctions?
ANS
cell-cell anchoring junction that links actin filaments
What are desmosomes?
ANS
cell-cell anchoring junction that links intermediate filaments
What filament forms a layer close to the cell surface?
ANS
actin
What are the two cell-matrix anchoring junctions?
ANS
actin-linked cell-matrix adhesions (focal adhesions) and hemidesmosomes
What are focal adhesions?
ANS
link actin filaments to the ECM
What are hemidesmosomes?
ANS
, Link intermediate filaments to the ECM
What are the two types of cadherins and what are the differences?
ANS
classical= named according to tissue they were first found
non-classical- more than 50 alone in brain
Where are each of these cadherins?
N-cadherin
P-cadherin
E-cadherin
ANS
N-cadherin --> nerve
P-cadherin--> placenta, epidermis
E-cadherin---> epithelial
What is the difference between homophilic and heterophilic binding?
ANS
Homophilic binding happens between molecules that are closely related or the same,
whereas heterophilic binding is between two totally different molecules
What happens to cadherin in the absence of Ca?
ANS
the cadherin molecules become floppy and interaction fails
How are cadherin molecules arranged? What does it resemble?
ANS
like velcro, arranged in parallel fashion
What allows dissociated cells or migrating cells to sort out and reassemble into
organized tissues?
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