Class notes
LE5 College aantekeningen Oncology (NWI-BM015C) Hereditary Tumors
- Course
- Institution
Summary lecture hereditary tumors for the course oncology. Including figures and important subjects for the exam in bold.
[Show more]
Seller
Follow
gertjanzutphen
Content preview
LE 5 – Hereditary tumorsNovember 24 t h , 2023
Oncogene
Growth stimulating properties
Gain of function mutations
o Activating mutation in one allele
Hardly ever basis of tumor susceptibility (exception RET >MEN2A (thyroid carcinomas)).
Activating mutations
Point mutation
Amplification
Chromosomal Translocation
Tumor suppressor genes
Gatekeepers (RB1, TP53)
o Apoptosis: programmed cell death
o Senescence: permanent withdrawal from the cell cycle
Caretakers (mismatch repair genes)
o Genome stability
Loss of function mutations
o Inactivation of both alleles at cellular level
Tumor susceptibility: inactivation of one allele in the germline
o Second hit:
Loss of wild type allele (LOH)
Epigenetic inactivation
Mutation
, The Knudson two-hit model of tumor initiation
Knudson two-hit model in unaffected individuals
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller gertjanzutphen. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $3.23. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
56326 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now