NR-565 Advanced Pharmacology Fundamentals Midterm Exam Q & A Study Set Pharmacokinetics Correct Answe r: The process by which drugs are absorbed, distributed within the body, metabolized, and excreted. Pharmacodynamics Correct Answer: The study of what the drug does to the body Cytochrome P450 (CYP450) Correct Answer: xenobiotic -metabolizing enzymes necessary for the production of cholesterol and steroids and the detoxification of chemicals and drug metabolism. Function of Cytochrome P450 (CYP450) Correct Answer: responsible for phase 1 metabolism in which drugs are oxidized, reduced, or hydrolyzed Three possible outcomes of phase 1 drug metabolism. Correct Answer: -Drug becomes completely inactive -Drug becom es partially inactive but one or more metabolites remain active -Original drug is not pharmacologically active but one metabolite remains active CRAP GPS induces my rage Correct Answer: CRAP GPS Carbamazepine Rifampin Alcohol Phenytoin Griseofulvin Phenobarbital Sulfonylureas VISA CK GQ Correct Answer: VISA CK GQ Valproate Isoniazid Sulfonamides Amiodarone Chloramphenicol Ketoconazole Grapefruit Juice Quinidine Beers Criteria Correct Answer: -potentially Inappropriate Medication (PIM) use in olde r adults -potentially Inappropriate Medication (PIM) use in older adults due to medication -disease or medication -syndrome interactions that may exacerbate the disease or syndrome -medications to be used cautiously in older adults -clinically significant dr ug interactions that should be avoided in older adults -medications to be avoided or dosage decreased in the presence of impaired kidney function in older adults Metabolism Interaction Correct Answer: concentration of the medication after biotransformation into active and inactive metabolites in higher or lower than expected. prescriptive authority Correct Answer: refers to the nurse practitioner's authority to prescribe medications. Full-practice s cope Correct Answer: Nurse practitioners have the autonomy to evaluate patients, diagnose, order and interpret tests, initiate and manage treatments and prescribe medications, including controlled substances without physician oversight. Reduced -practice scope Correct Answer: Nurse practitioners are limited in at least one element of practice. The state requires a formal collaborative agreement with an outside health discipline for the nurse practitioner to provide patient care. Restricted practice scope Correct Answer: Nurse practitioners are limited in at least one element of practice by requiring supervision, delegation, or team management by an outside health discipline for the nurse practitioner to provide patient care. Opioids Correct Answer: any drug, natural or synthetic, that has actions similar to those of morphine
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