100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Summary phys.theory: ALS $5.42   Add to cart

Summary

Summary phys.theory: ALS

 1 view  0 purchase
  • Course
  • Institution

Summary of the ALS lesson given by prof. E. van Camp from the subject of physiotherapeutic theory. It is a summary of the powerpoint slides and additional items noted during the lesson. The slides were in English and my own notes are always in Dutch as much as possible. It is therefore a mix of the...

[Show more]

Preview 2 out of 15  pages

  • December 17, 2023
  • 15
  • 2023/2024
  • Summary
avatar-seller
Physioth. Theory: ALS

CLINICAL PRESENTATION OF ALS
 Neurological degenerative disease
 Prevalence: 10-12/100.000
- Grote var.
 Incidence: 1,7-3/100,000 year
 Male-female ratio 1,2-1,5
 Age onset: 58-63
 Survival: 2-5 years
 Cause of death: respiratory failure
- Pneumonias -> overnight ventilation -> 24h ventilation
- In & expiratoire spieren verzwakken

GENETIC FEATURES
 10% familial , 90% sporadic
- Sporadic ALS: also gene mutations
 15% genetic cause is known, 85% unknown
 C9orf72 50% fALS, 7% sALS
 SOD1 20% fALS 1% sALS
 FUS &TARDBP 2-3% fALS

Involvement zeer belangrijk

 UMN involvement:
- Corticospinal tract
 Limb onset
 Spasticiteit
 Soms ook spraak
- Corticobulbar tract
 Spraak
 Respiratoir
 Slik problemen
 LMN involvement:
- Spinomuscular tract
 Hand & voeten atrofie
 hypotonia

PRECEDING SYMPTOMS (BEFORE WEAKNESS)
 Muscle cramps
 Fasciculations
- You can see the muscle fibres twitching, during the day not painfull but when they want to go to sleep it can
be disturbing
- Spiervezels zien bibberen onder huid
 Weight loss




Nala Melis Pagina 1

, Physioth. Theory: ALS
DISEASE ONSET
 What is the onset and what symptoms come first and which ones later?
 3 grote groepen= phenotypes

1. SPINAL ONSET
 Often asymmetrical weakness
 Distal > proxilam, arms > legs
 Hypotonia or spasticity
o Hypotonia = LMN
o Spasticity = involvement of UMN
UL onset LL onset
 Langere levensverwachting dan bulbar onset
2. BULBAR ONSET
 Dysphagia: swallowing, chewing problems
 Dysarthria= meeste
 Emotional lability
- Laughing or crying for no reason
 First respiratory physiotherapy, after those problems it will go to the UL and later to the LL
 Geen afasia

3. RESPIRATORY ONSET
 Zeer zeldzaam
 Weakness of respiratory muscles
 Dyspnoea, orthopnoea, morning headache
 Following with upper limb, trunk weakness
 First symptom is shortness of breath especially while sleeping o P is lying down = weakness of diaphragm
- Difficulty falling to sleep and continuing to sleep
- CO2 levels are rising -> brain centres pick this up and the patient will wake up
- Morning headache due to the rising CO2 levels
 Hypoventilatie tijdens slapen
 Zeer lage levensverwachting
 Gaan aan vent. Moeten & nadien kome er nog voedingsproblemen bij

ALS VARIANTS

 Niet gediagnostiseerd met ALS in die fase
- Diagnose kan witchen bij progressie/ over tijd

1. PRIMARY LATERAL SCLEROSIS – PLS
 Only upper motor neuron involvement
 75% of all patients evolve to ALS within the first 4 years, if not longer survival
 Could evolve to ALS in the first years
 Corticospinal and corticobulbar tract involvement
 slowly progressive, survival 3-30 years

2. PROGRESSIVE MUSCULAR ATROPHY – PMA
 Only lower motor neuron involvement
 flail arm or leg syndrome
 Progression to ALS first 4 years if not better survival
 Mean survival 4y, could be quicker or slower progressive then ALS
 Could be both of the legs or both of the arms
 Flail leg – gait parameters
- Hyperextension of the knees -> paresis of hamstrings and quadriceps
- Drop foot: they fall down, he is not able to activate the TA eccentrically


 Flail arm – gait parameters

Nala Melis Pagina 2

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller NM99. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for $5.42. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

64438 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy study notes for 14 years now

Start selling
$5.42
  • (0)
  Add to cart