Exam (elaborations)
APHON Principles Of Biotherapy – Questions With Complete Solutions
- Course
- Institution
APHON Principles Of Biotherapy – Questions With Complete Solutions
[Show more]
Seller
Follow
LeCrae
Reviews received
Content preview
APHON Principles Of Biotherapy – Questions WithComplete Solutions
Biotherapy ✔️Ans - modality of tx: agents that resemble body's own defense
and surveillance systems. can augment/modulate/restore host's immune
response, direct antitumor activity, other biological effects. side effects
typically hypersensitivity rx
Immune surveillance ✔️Ans - tumor cells express abnormal tumor antigens
on surface that can be recognized/destroyed by immune system
Natural killer cells ✔️Ans - lymphocyte that recognizes/kills malignant cells
Cytotoxic t cells ✔️Ans - recognize tumor-assosiated antigens and kills cells
interferons ✔️Ans - multiple moa's & produced w/ recombinant dna.
protein capable of protecting other cells from viral infections by interfering
w/ viral replication.
family of glycoproteins include: antiviral, antiproliferative, potent
immunomodulatory effects
cytokines ✔️Ans - products of immune cells to enhance cytotoxic activity of
cells and increase immune response
alpha-interferon ✔️Ans - leukocyte-derived. tx: hairy cell leukemia,
melanoma, chronic myeloid leukemia, follicular lymphoma, multiple myeloma,
cutaneous t-cell lymphoma
beta-interferon ✔️Ans - fibroblast-derived. tx MS
gamma-interferon ✔️Ans - t-lymphocyte derived. tx chronic granulomatus
disease
interleukin-2 ✔️Ans - produced by t-helper cells & stimulate
growth/maturation of t-cell subsets, cytotoxic t-cells, production of
lymphokines & cytokines.
act as chemical signals b/w wbc's (revs up immune system)
, retinoids ✔️Ans - immunomodulators that facilitate differentiation &
suppress proliferation of cancer cells
all-trans retinoic acid (atra) ✔️Ans - tx: aml, aml m3 subtype, apl
increase maturation of promyelocytic blasts and rapid resolution of
coagulopathy r/t tx.
isotretinoin (accutane) ✔️Ans - retinoid tx neuroblastoma.
have antitumor activity unknown moa. TERATOGENIC. male/female pt must
register iPledge (fetal exposure). can also affect hearing & vision
antibodies ✔️Ans - proteins produced by b-lymphocytes. part of humoral
immunity of adaptive system. includes immunoglobulins (igG, igA, igM, igE,
igD)
murine ✔️Ans - mouse-derived MoAbs. pt develops human antimouse
antibodies creating high risk of hypersensitivity rx
end in -momab
Monoclonal antibodies ✔️Ans - very specific. directed against single
antigenic determinant on cell surface causing antibody-dependent cellular
toxicity, direct cell death, elimination of antigen/target cell that expresses the
antigen
low toxicity
-ximab ✔️Ans - moab combo of human & mouse antibodies
-zumab ✔️Ans - moab humanized, small part of mouse antibody fused w/
human antibody
-umab ✔️Ans - fully humanized moabs
chimeric moab ✔️Ans - murine variable & human constant coupled using
recombinant dna
purpose of moabs ✔️Ans - attach low-dose radioisotopes to image residual
disease. target chemo, radiation, biotherapy to tumor
purge autologous bone marrow of cancer cells before transplant
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller LeCrae. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $9.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
83637 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now