MSK - Week 6 (+review session) Diseases, Disorders, Things that Go Wrong
2 views 0 purchase
Course
HIM 350
Institution
Southern New Hampshire University
MSK - Week 6 (+review session) Diseases, Disorders, Things that Go Wrong
osteochondroma is AKA exostosis
osteochondroma definition benign cartilage-capped tumor, attached to the underlying skeleton by a bony stalk (extension of the cartilaginous plate)
osteochondroma ...
MSK - Week 6 (+review session)
Diseases, Disorders, Things that Go
Wrong
osteochondroma is AKA exostosis
osteochondroma definition benign cartilage-capped tumor, attached to the underlying skeleton
by a bony stalk (extension of the cartilaginous plate)
osteochondroma epidemiology 10-30 yrs
osteochondroma presentation - "incidental" finding or pain in long bone metaphysis
- 1-20 cm in size
- typically stop growing with normal growth plates: lesions may rarely progress to
chondrosarcoma
osteochondroma pathology - cartilaginous cap
- disorganized growth plate with ossification towards the base
osteochondroma site metaphysis near the growth plate of long tubular bones, especially near
knee
Chondroma (Enchondroma) signs/symptoms- often asymptomatic
, - radiology shows central calcification, thin cortex
Chondroma pathologybenign cartilage and reactive bone
Chondroma (Enchondroma) genetics germline loss of function mutations in EXT1 or EXT2
genes (abnormal chondrocyte development)
Enchondroma Benign tumor consisting of cartilage in medullary cavity
Juxtacortical chondroma chondroma on bone surface
chondroblastoma definition benign, chondroid-producing neoplasm composed of chondroblasts
chondroblastoma signs/symptoms - lytic lesion in long bone epiphysis, well-defined margins
- mature cartilage
- insidious onset of bone pain, local swelling, joint stiffness, effusion, limp
- skull bone tumors -> seizures and progressive hearing loss
chondroblastoma site long bone epiphysis
chondroblastoma pathology "chicken wire" matrix = mature or immature chondroid cells and
poorly formed matrix
chondromyxoid fibroma definition benign cartilaginous tumor of young adults, arising in
proximal or distal parts of long bones
chondromyxoid fibroma signs/symptoms - pain/swelling/tenderness/stiffness
- radiology:
- geographic bone destruction
- sclerotic rim
- lobated/scalloped margins
- internal trabeculations
chondromyxoid fibroma sites proximal or distal parts of long bones
chondromyxoid fibroma pathology chondrocytes in various stages of maturation
chondrosarcoma definition malignant tumors that produce cartilage
chondrosarcoma epidemiology age >40s
males>females
chondrosarcoma signs/symptoms - pain, swelling, pain
- pathological fracture
- palpable lump or local mass effect
- nodular, glistening gross appearance of bone
- p53 loss
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller docguru. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $11.29. You're not tied to anything after your purchase.
