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Etiologia y diagnostico dd Anemia Megaloblasticas
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03ANEMIA ME-
GALOBLÁSTICA
, deficiencia de folato o vit. B12 → tienen en común una
ANEMIA MEGALOBLASTICA CAUSA alteración en la síntesis del ADN
⬇ Hb ⬆Tamaño de Cell
Eritrocitos
Eritrocitos ovalados anormalmente grandes
ÁCIDO FOLICO (VIT B9) TRANSPORTE ⅓ → ALBÚMINA / ⅔ → ESTADO LIBRE
FOLATO ALIMENTARIO
ABSORCIÓN
70%-90% → Poliglutamatos de folato
⬆Yeyuno
Calentamiento Folato
ALIMENTOS QUE POSEE ⬆⬆FOLATO
Poliglutamato
Higado, Levadura, Espinaca, Vegetales
Verdes y granos
Monoglutamato
Necesidades diarias:
- en el adulto → 100ug
5 - metilTHF (5 - MTHF)
- Gestación → 400 ug
Reservas → 3 - 4 meses (⬆⬆HIGADO)
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