Summary
Samenvatting endocrinologie - Baert
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nelhofman
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ENDOCRINOLOGIEDE HYPOFYSE
ACROMEGALIE OF REUZEGROEI
Niet-aangeboren en zeldzame aandoening v.d. hypofyse
Blijvende stimulatie tot productie vh groeihormoon door aanwezig tumor meestal goedaardig adenoom
Tumor ih deel vd hypofyse dat groeihormoon produceert
Ontstaan 30 – 50 jaar
Bijna nooit erfelijk
Symptomen
Eerste symptomen:
o Hoofdpijn door vergroting hyposfyse door tumor
o Algemene vermoeidheid
o Gewrichtspijn
o Toegenomen transpiratie
o Zwelling v. zachte weefsels
o Problemen gezichtsvermogen tumor druk op oogzenuwen
Uiterlijke kenmerken:
o Extremiteiten vergroten:
Handen, voeten, oren, neusbasis, onderkaak
o Bij kinderen die nog niet volgroeid zijn, groeischijven nog actief = blijven groeien (2,5 meter)
Andere:
o Organomegalie lever, hart en nieren
o Overmatige transpiratie vettige huid
o Soms tintelingen of pijn if handen
Behandeling:
Afgestemd volgens de individuele symptomen en mogelijke outcome
o Medicamenteus:
Groeiremmende hormonen stabilseren
o Operatief
Transsfenoïdale operatie via sfenoidholte boven neusholte naar bodem vh turkse
zadel (hypofyse)
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