contraindications acetaminophen? - long term use during pregnancy associated with ADHD
- severe inflammatory pain (not best to give)
- severe hepatic disease
MOA salicylates (acetylsalicylic acid, aspirin) inhibits COX which inhibits the synthesis of
prostaglandins
- antipyretic, analgesic, anti-platelet properties
MOA NSAIDs inhibits prostaglandin biosynthesis via inhibition of COX isoenzymes
(COX1/COX2)
side effects NSAIDs - similar to aspirin
- can precipitate asthma/anaphylactoid reactions
- reversible platelet inhibition
- hepatotoxicity
- CV risk
- people with PUD history should be tested for H.Pylori
- monitor renal function
indications NSAIDs? - pain (more effective than tylenol)
- fever
- colon cancer prevention
- PDA closure
- stabilize menstrual bleeding
side effects TCAs dry. mouth, weight gain, dizziness, tremor, urinary retention, confusion,
sedation
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